An overview of microbial indigo-forming enzymes

Andrea N. Fabara, Marco W. Fraaije*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
121 Downloads (Pure)

Abstract

Indigo is one of the oldest textile dyes and was originally prepared from plant material. Nowadays, indigo is chemically synthesized at a large scale to satisfy the demand for dyeing jeans. The current indigo production processes are based on fossil feedstocks; therefore, it is highly attractive to develop a more sustainable and environmentally friendly biotechnological process for the production of this popular dye. In the past decades, a number of natural and engineered enzymes have been identified that can be used for the synthesis of indigo. This mini-review provides an overview of the various microbial enzymes which are able to produce indigo and discusses the advantages and disadvantages of each biocatalytic system.

Original languageEnglish
Pages (from-to)925-933
Number of pages9
JournalApplied Microbiology and Biotechnology
Volume104
Issue number3
Early online date13-Dec-2019
DOIs
Publication statusPublished - 1-Feb-2020

Keywords

  • Indigo
  • Indole
  • Naphthalene dioxygenase
  • Styrene monoxygenase
  • P450 monoxygenase
  • Peroxygenase
  • Flavoprotein monooxygenase
  • FLAVIN-CONTAINING MONOOXYGENASE
  • ESCHERICHIA-COLI
  • STYRENE MONOOXYGENASE
  • PHENOL HYDROXYLASE
  • SOIL METAGENOME
  • GENE-CLUSTER
  • CLONING
  • INDOLE
  • IDENTIFICATION
  • EXPRESSION

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