An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery

Renée S. van der Kooij, Rob Steendam, Henderik W. Frijlink, Wouter L.J. Hinrichs*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)
393 Downloads (Pure)

Abstract

Core-shell microspheres hold great promise as a drug delivery system because they offer several benefits over monolithic microspheres in terms of release kinetics, for instance a reduced initial burst release, the possibility of delayed (pulsatile) release, and the possibility of dual-drug release. Also, the encapsulation efficiency can significantly be improved. Various methods have proven to be successful in producing these core-shell microspheres, both the conventional bulk emulsion solvent evaporation method and methods in which the microspheres are produced drop by drop. The latter have become increasingly popular because they provide improved control over the particle characteristics. This review assesses various production methods for core-shell microspheres and summarizes the characteristics of formulations prepared by the different methods, with a focus on their release kinetics.

Original languageEnglish
Pages (from-to)24-42
Number of pages19
JournalEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Volume170
DOIs
Publication statusPublished - 1-Jan-2022

Keywords

  • Biodegradable polymer
  • Bulk emulsion solvent evaporation method
  • Controlled release
  • Core-shell microspheres
  • Drop-by-drop production methods
  • Drug delivery

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