TY - JOUR
T1 - An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery
AU - van der Kooij, Renée S.
AU - Steendam, Rob
AU - Frijlink, Henderik W.
AU - Hinrichs, Wouter L.J.
N1 - Publisher Copyright:
Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Core-shell microspheres hold great promise as a drug delivery system because they offer several benefits over monolithic microspheres in terms of release kinetics, for instance a reduced initial burst release, the possibility of delayed (pulsatile) release, and the possibility of dual-drug release. Also, the encapsulation efficiency can significantly be improved. Various methods have proven to be successful in producing these core-shell microspheres, both the conventional bulk emulsion solvent evaporation method and methods in which the microspheres are produced drop by drop. The latter have become increasingly popular because they provide improved control over the particle characteristics. This review assesses various production methods for core-shell microspheres and summarizes the characteristics of formulations prepared by the different methods, with a focus on their release kinetics.
AB - Core-shell microspheres hold great promise as a drug delivery system because they offer several benefits over monolithic microspheres in terms of release kinetics, for instance a reduced initial burst release, the possibility of delayed (pulsatile) release, and the possibility of dual-drug release. Also, the encapsulation efficiency can significantly be improved. Various methods have proven to be successful in producing these core-shell microspheres, both the conventional bulk emulsion solvent evaporation method and methods in which the microspheres are produced drop by drop. The latter have become increasingly popular because they provide improved control over the particle characteristics. This review assesses various production methods for core-shell microspheres and summarizes the characteristics of formulations prepared by the different methods, with a focus on their release kinetics.
KW - Biodegradable polymer
KW - Bulk emulsion solvent evaporation method
KW - Controlled release
KW - Core-shell microspheres
KW - Drop-by-drop production methods
KW - Drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85123652067&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2021.11.007
DO - 10.1016/j.ejpb.2021.11.007
M3 - Review article
C2 - 34861359
AN - SCOPUS:85123652067
SN - 0935-1221
VL - 170
SP - 24
EP - 42
JO - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ER -