An updated structural classification of substrate-binding proteins

Giel H. Scheepers, Jelger A. Lycklama A Nijeholt, Bert Poolman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

87 Citations (Scopus)

Abstract

Substrate-binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010 Berntsson et al. classified the 114 organism-specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then the number of unique SBP structures has increased almost 5-fold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now sub-classify the SBPs within the original clusters. Moreover, we propose a 7(th) cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins. This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)4393-4401
Number of pages9
JournalFEBS Letters
Volume590
Issue number23
Early online date23-Oct-2016
DOIs
Publication statusPublished - Dec-2016

Keywords

  • ABC transporter
  • membrane protein
  • signal transduction
  • solute transport
  • structural classification
  • substrate-binding protein
  • SPHINGOMONAS SP A1
  • ABC TRANSPORTERS
  • CRYSTAL-STRUCTURE
  • LIGAND-BINDING
  • CASSETTE TRANSPORTER
  • ESCHERICHIA-COLI
  • SOLUTE RECEPTOR
  • MECHANISM
  • FAMILY
  • DIVERSITY

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