Anemia is associated with an increased central venous pressure and mortality in a broad spectrum of cardiovascular patients

Lennaert Kleijn; B. Daan Westenbrink; Vincent M. van Deursen; Kevin Damman; Rudolf A. de Boer; Hans Hillege; Dirk J. van Veldhuisen; Adriaan A. Voors; Peter van der Meer

doi:10.1007/s00392-014-0673-7

Anemia is associated with an increased central venous pressure and mortality in a broad spectrum of cardiovascular patients

Lennaert Kleijn, B. Daan Westenbrink, Vincent M. van Deursen, Kevin Damman, Rudolf A. de Boer, Hans Hillege, Dirk J. van Veldhuisen, Adriaan A. Voors, Peter van der Meer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Background Anemia is frequently observed in patients with cardiovascular disease. Multiple factors have been associated with anemia, but the role of hemodynamics is largely unknown. Therefore, we investigated the association between hemoglobin (Hb) levels, hemodynamics and outcome in a broad spectrum of cardiovascular patients.

Methods and results A total of 2,009 patients who underwent right heart catheterization at the University Medical Center Groningen, the Netherlands, between 1989 and 2006 were identified and data were extracted from electronic databases. Anemia was defined by the WHO criteria (male, hemoglobin

Conclusion Anemia is common in cardiovascular patients and independently related to an elevated CVP and CI. Patients with anemia and an elevated CVP have the worst prognosis.

Original language	English
Pages (from-to)	467-476
Number of pages	10
Journal	Clinical Research in Cardiology
Volume	103
Issue number	6
DOIs	https://doi.org/10.1007/s00392-014-0673-7
Publication status	Published - Jun-2014

Keywords

Heart failure
Anemia
Hemoglobin
Hemodynamics
CHRONIC HEART-FAILURE
ACUTE MYOCARDIAL-INFARCTION
HEMOGLOBIN CONCENTRATION
OXYGEN AVAILABILITY
PROGNOSTIC VALUE
RENAL-FUNCTION
DYSFUNCTION
CORONARY
PATHOPHYSIOLOGY
HEMODILUTION

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Anemia is associated with an increased central venous pressure and mortality
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Kleijn, L., Westenbrink, B. D., van Deursen, V. M., Damman, K., de Boer, R. A., Hillege, H., van Veldhuisen, D. J., Voors, A. A., & van der Meer, P. (2014). Anemia is associated with an increased central venous pressure and mortality in a broad spectrum of cardiovascular patients. Clinical Research in Cardiology, 103(6), 467-476. https://doi.org/10.1007/s00392-014-0673-7

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title = "Anemia is associated with an increased central venous pressure and mortality in a broad spectrum of cardiovascular patients",

abstract = "Background Anemia is frequently observed in patients with cardiovascular disease. Multiple factors have been associated with anemia, but the role of hemodynamics is largely unknown. Therefore, we investigated the association between hemoglobin (Hb) levels, hemodynamics and outcome in a broad spectrum of cardiovascular patients.Methods and results A total of 2,009 patients who underwent right heart catheterization at the University Medical Center Groningen, the Netherlands, between 1989 and 2006 were identified and data were extracted from electronic databases. Anemia was defined by the WHO criteria (male, hemoglobinConclusion Anemia is common in cardiovascular patients and independently related to an elevated CVP and CI. Patients with anemia and an elevated CVP have the worst prognosis.",

keywords = "Heart failure, Anemia, Hemoglobin, Hemodynamics, CHRONIC HEART-FAILURE, ACUTE MYOCARDIAL-INFARCTION, HEMOGLOBIN CONCENTRATION, OXYGEN AVAILABILITY, PROGNOSTIC VALUE, RENAL-FUNCTION, DYSFUNCTION, CORONARY, PATHOPHYSIOLOGY, HEMODILUTION",

author = "Lennaert Kleijn and Westenbrink, {B. Daan} and {van Deursen}, {Vincent M.} and Kevin Damman and {de Boer}, {Rudolf A.} and Hans Hillege and {van Veldhuisen}, {Dirk J.} and Voors, {Adriaan A.} and {van der Meer}, Peter",

year = "2014",

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doi = "10.1007/s00392-014-0673-7",

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T1 - Anemia is associated with an increased central venous pressure and mortality in a broad spectrum of cardiovascular patients

AU - Kleijn, Lennaert

AU - Westenbrink, B. Daan

AU - van Deursen, Vincent M.

AU - Damman, Kevin

AU - de Boer, Rudolf A.

AU - Hillege, Hans

AU - van Veldhuisen, Dirk J.

AU - Voors, Adriaan A.

AU - van der Meer, Peter

PY - 2014/6

Y1 - 2014/6

N2 - Background Anemia is frequently observed in patients with cardiovascular disease. Multiple factors have been associated with anemia, but the role of hemodynamics is largely unknown. Therefore, we investigated the association between hemoglobin (Hb) levels, hemodynamics and outcome in a broad spectrum of cardiovascular patients.Methods and results A total of 2,009 patients who underwent right heart catheterization at the University Medical Center Groningen, the Netherlands, between 1989 and 2006 were identified and data were extracted from electronic databases. Anemia was defined by the WHO criteria (male, hemoglobinConclusion Anemia is common in cardiovascular patients and independently related to an elevated CVP and CI. Patients with anemia and an elevated CVP have the worst prognosis.

AB - Background Anemia is frequently observed in patients with cardiovascular disease. Multiple factors have been associated with anemia, but the role of hemodynamics is largely unknown. Therefore, we investigated the association between hemoglobin (Hb) levels, hemodynamics and outcome in a broad spectrum of cardiovascular patients.Methods and results A total of 2,009 patients who underwent right heart catheterization at the University Medical Center Groningen, the Netherlands, between 1989 and 2006 were identified and data were extracted from electronic databases. Anemia was defined by the WHO criteria (male, hemoglobinConclusion Anemia is common in cardiovascular patients and independently related to an elevated CVP and CI. Patients with anemia and an elevated CVP have the worst prognosis.

KW - Heart failure

KW - Anemia

KW - Hemoglobin

KW - Hemodynamics

KW - CHRONIC HEART-FAILURE

KW - ACUTE MYOCARDIAL-INFARCTION

KW - HEMOGLOBIN CONCENTRATION

KW - OXYGEN AVAILABILITY

KW - PROGNOSTIC VALUE

KW - RENAL-FUNCTION

KW - DYSFUNCTION

KW - CORONARY

KW - PATHOPHYSIOLOGY

KW - HEMODILUTION

U2 - 10.1007/s00392-014-0673-7

DO - 10.1007/s00392-014-0673-7

M3 - Article

SN - 1861-0684

VL - 103

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EP - 476

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

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