Angina pectoris refractory for conventional therapy - Is neurostimulation a possible alternative treatment?

RWM Hautvast*, MJL DeJongste, GJ TerHorst, PK Blanksma, KI Lie

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    The treatment of angina pectoris as a symptom of coronary artery disease usually is focused on restoring the balance between oxygen demand and supply of the myocardium by administration of drugs interfering in heart rate, cardiac pre- and afterload, and coronary vascular tone. For nonresponders to drug therapy or for those with jeopardized myocardium, revascularization procedures such as coronary bypass surgery and percutaneous transluminal coronary angioplasty are at hand. However, the atherosclerotic process is not stopped by these therapies and, at longer terms, angina may recur. It is not always possible to revascularize all the patients who do not positively react to medical treatment. Those with angina, not responding to adequate medication and who are not suitable anymore for revascularization, are considered to suffer from refractory angina pectoris. This group of patients has a poor quality of life, for their exercise tolerance is severely afflicted. For these patients, neurostimulation has been described repeatedly as an effective and safe therapy. The mechanism of action of neurostimulation is not completely known, but recent studies suggest an anti-ischemic effect, exerted through changes in myocardial blood flow. As soon as its safety is sufficiently established, it may become a useful alternative in the treatment of refractory angina pectoris.

    Original languageEnglish
    Pages (from-to)531-535
    Number of pages5
    JournalClinical Cardiology
    Volume19
    Issue number7
    Publication statusPublished - Jul-1996

    Keywords

    • refractory angina pectoris
    • neurostimulation
    • redistribution
    • coronary flow
    • SPINAL-CORD STIMULATION
    • ELECTRICAL NERVE-STIMULATION
    • PERIPHERAL VASCULAR-DISEASE
    • DORSAL COLUMN STIMULATION
    • SEVERE LIMB ISCHEMIA
    • BLOOD-FLOW
    • PAIN RELIEF
    • MYOCARDIAL ISCHEMIA
    • HORN NEURONS
    • MECHANISMS

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