Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU

G. Sussman; M. Abuzakouk; F. Berard; W. Canonica; H. N. G. Oude Elberink; A. Gimenez-Arnau; C. Grattan; K. Hollis; S. Hunter; A. Knulst; J. -P. Lacour; C. Lynde; A. Marsland; D. McBride; M. Maurer; A. Nakonechna; J. Ortiz de Frutos; M. Reynolds; C. Sweeney; H. Tian; K. Weller; D. Wolin; M. -M. Balp

doi:10.1111/all.13430

Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU

G. Sussman^*, M. Abuzakouk, F. Berard, W. Canonica, H. N. G. Oude Elberink, A. Gimenez-Arnau, C. Grattan, K. Hollis, S. Hunter, A. Knulst, J. -P. Lacour, C. Lynde, A. Marsland, D. McBride, M. Maurer, A. Nakonechna, J. Ortiz de Frutos, M. Reynolds, C. Sweeney, H. TianK. Weller, D. Wolin, M. -M. Balp

^*Corresponding author for this work

Groningen Research Institute for Asthma and COPD (GRIAC)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BackgroundASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.

MethodsThis international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data. Patients in the Yes-angioedema category had angioedema reported in the medical record and a patient-reported source. For those in the No-angioedema category, angioedema was reported in neither the medical record nor a patient-reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes-angioedema and No-angioedema categories were conducted for measures of CSU activity, health-related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates.

ResultsAmong evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes-angioedema, No-angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes-angioedema patients than No-angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, P

ConclusionsAngioedema in CSU seems to be under-reported but has significant negative impacts on HRQoL, daily activities, HCRU and work compared with no angioedema.

Original language	English
Pages (from-to)	1724-1734
Number of pages	11
Journal	Allergy
Volume	73
Issue number	8
DOIs	https://doi.org/10.1111/all.13430
Publication status	Published - Aug-2018

Keywords

angioedema
economic burden
observational study
quality of life
urticaria
QUALITY-OF-LIFE
CHRONIC IDIOPATHIC URTICARIA
DISEASE-ACTIVITY
DAILY DIARY
REAL-WORLD
QUESTIONNAIRE
OMALIZUMAB
VALIDATION
BURDEN

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Sussman, G., Abuzakouk, M., Berard, F., Canonica, W., Oude Elberink, H. N. G., Gimenez-Arnau, A., Grattan, C., Hollis, K., Hunter, S., Knulst, A., Lacour, J. .-P., Lynde, C., Marsland, A., McBride, D., Maurer, M., Nakonechna, A., Ortiz de Frutos, J., Reynolds, M., Sweeney, C., ... Balp, M. .-M. (2018). Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU. Allergy, 73(8), 1724-1734. https://doi.org/10.1111/all.13430

@article{c191629fa094436b856adc60b14956e7,

title = "Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU",

abstract = "BackgroundASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.MethodsThis international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data. Patients in the Yes-angioedema category had angioedema reported in the medical record and a patient-reported source. For those in the No-angioedema category, angioedema was reported in neither the medical record nor a patient-reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes-angioedema and No-angioedema categories were conducted for measures of CSU activity, health-related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates.ResultsAmong evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes-angioedema, No-angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes-angioedema patients than No-angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, PConclusionsAngioedema in CSU seems to be under-reported but has significant negative impacts on HRQoL, daily activities, HCRU and work compared with no angioedema.",

keywords = "angioedema, economic burden, observational study, quality of life, urticaria, QUALITY-OF-LIFE, CHRONIC IDIOPATHIC URTICARIA, DISEASE-ACTIVITY, DAILY DIARY, REAL-WORLD, QUESTIONNAIRE, OMALIZUMAB, VALIDATION, BURDEN",

author = "G. Sussman and M. Abuzakouk and F. Berard and W. Canonica and {Oude Elberink}, {H. N. G.} and A. Gimenez-Arnau and C. Grattan and K. Hollis and S. Hunter and A. Knulst and Lacour, {J. -P.} and C. Lynde and A. Marsland and D. McBride and M. Maurer and A. Nakonechna and {Ortiz de Frutos}, J. and M. Reynolds and C. Sweeney and H. Tian and K. Weller and D. Wolin and Balp, {M. -M.}",

year = "2018",

month = aug,

doi = "10.1111/all.13430",

language = "English",

volume = "73",

pages = "1724--1734",

journal = "Allergy",

issn = "0105-4538",

publisher = "Wiley-Blackwell",

number = "8",

}

Sussman, G, Abuzakouk, M, Berard, F, Canonica, W, Oude Elberink, HNG, Gimenez-Arnau, A, Grattan, C, Hollis, K, Hunter, S, Knulst, A, Lacour, J-P, Lynde, C, Marsland, A, McBride, D, Maurer, M, Nakonechna, A, Ortiz de Frutos, J, Reynolds, M, Sweeney, C, Tian, H, Weller, K, Wolin, D & Balp, M-M 2018, 'Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU', Allergy, vol. 73, no. 8, pp. 1724-1734. https://doi.org/10.1111/all.13430

TY - JOUR

T1 - Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact

T2 - Analyses from ASSURE-CSU

AU - Sussman, G.

AU - Abuzakouk, M.

AU - Berard, F.

AU - Canonica, W.

AU - Oude Elberink, H. N. G.

AU - Gimenez-Arnau, A.

AU - Grattan, C.

AU - Hollis, K.

AU - Hunter, S.

AU - Knulst, A.

AU - Lacour, J. -P.

AU - Lynde, C.

AU - Marsland, A.

AU - McBride, D.

AU - Maurer, M.

AU - Nakonechna, A.

AU - Ortiz de Frutos, J.

AU - Reynolds, M.

AU - Sweeney, C.

AU - Tian, H.

AU - Weller, K.

AU - Wolin, D.

AU - Balp, M. -M.

PY - 2018/8

Y1 - 2018/8

N2 - BackgroundASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.MethodsThis international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data. Patients in the Yes-angioedema category had angioedema reported in the medical record and a patient-reported source. For those in the No-angioedema category, angioedema was reported in neither the medical record nor a patient-reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes-angioedema and No-angioedema categories were conducted for measures of CSU activity, health-related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates.ResultsAmong evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes-angioedema, No-angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes-angioedema patients than No-angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, PConclusionsAngioedema in CSU seems to be under-reported but has significant negative impacts on HRQoL, daily activities, HCRU and work compared with no angioedema.

AB - BackgroundASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.MethodsThis international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data. Patients in the Yes-angioedema category had angioedema reported in the medical record and a patient-reported source. For those in the No-angioedema category, angioedema was reported in neither the medical record nor a patient-reported source. Those in the Misaligned category had angioedema reported in only one source. Statistical comparisons between Yes-angioedema and No-angioedema categories were conducted for measures of CSU activity, health-related quality of life (HRQoL), productivity and healthcare resource utilization (HCRU). Regression analyses explored the relationship between Dermatology Life Quality Index (DLQI) score and angioedema, adjusting for important covariates.ResultsAmong evaluable patients, 259 (40.3%), 173 (26.9%) and 211 (32.8%) were in the Yes-angioedema, No-angioedema and Misaligned category, respectively. CSU activity and impact on HRQoL, productivity, and HCRU was greater for Yes-angioedema patients than No-angioedema patients. After covariate adjustment, mean DLQI score was significantly higher (indicating worse HRQoL) for patients with angioedema versus no angioedema (9.88 vs 7.27, PConclusionsAngioedema in CSU seems to be under-reported but has significant negative impacts on HRQoL, daily activities, HCRU and work compared with no angioedema.

KW - angioedema

KW - economic burden

KW - observational study

KW - quality of life

KW - urticaria

KW - QUALITY-OF-LIFE

KW - CHRONIC IDIOPATHIC URTICARIA

KW - DISEASE-ACTIVITY

KW - DAILY DIARY

KW - REAL-WORLD

KW - QUESTIONNAIRE

KW - OMALIZUMAB

KW - VALIDATION

KW - BURDEN

U2 - 10.1111/all.13430

DO - 10.1111/all.13430

M3 - Article

SN - 0105-4538

VL - 73

SP - 1724

EP - 1734

JO - Allergy

JF - Allergy

IS - 8

ER -

Angioedema in chronic spontaneous urticaria is underdiagnosed and has a substantial impact: Analyses from ASSURE-CSU

Abstract

Keywords

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