Angiotensin-converting enzyme gene I/D polymorphism and renal disease

G Navis*, FGH van der Kleij, D de Zeeuw, PE de Jong

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

39 Citations (Scopus)

Abstract

In recent years a vast amount of data has been published on the association between the insertion/deletion (VD) polymorphism of the gene coding for angiotensin-converting enzyme and renal disease. It has be come clear that the polymorphism does not affect the prevalence of renal disease. However, data on the association with progression of renal disease and therapy response are still contradictory. Moreover, sufficient data on the physiological significance of this polymorphism are still lacking. This contribution provides an overview of the available studies and the potential pitfalls in interpreting the data. We also discuss the putative mechanisms for the association between the DD genotype and progression of renal disease and suggest directions for the future that might be employed to further clarify the role in renal pathophysiology.

Original languageEnglish
Pages (from-to)781 - 791
Number of pages11
JournalJournal of Molecular Medicine
Volume77
Issue number11
Publication statusPublished - Nov-1999

Keywords

  • ACE I/D polymorphism
  • genetic polymorphism
  • renal disease
  • ACE inhibitors
  • progressive renal disease
  • FOCAL SEGMENTAL GLOMERULOSCLEROSIS
  • INSERTION DELETION POLYMORPHISM
  • PLASMINOGEN-ACTIVATOR INHIBITOR-1
  • POLYCYSTIC KIDNEY-DISEASE
  • DIABETIC NEPHROPATHY
  • ACE GENE
  • IGA NEPHROPATHY
  • MYOCARDIAL-INFARCTION
  • BLOOD-PRESSURE
  • DIPEPTIDYL CARBOXYPEPTIDASE-1

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