Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof

Jan M. A. van Deursen (Inventor), Darren J. Baker (Inventor), James L. Kirkland (Inventor), Tamara Tchkonia (Inventor), Judith Campisi (Inventor), Marco Demaria (Inventor), Remi-Martin Laberge (Inventor)

Research output: Patent

Abstract

This disclosure provides non-human animal models for
age-related disorders and age-sensitive traits, particularly
those caused by senescence-inducing stimuli, wherein the
models comprise transgenes selectively expressed by senescent
cells. The disclosure further provides methods for
identifying therapeutic agents effective for treating or preventing
age-related disorders and age-sensitive traits using
the animal models, therapeutic agents identified using such
methods, pharmaceutical compositions comprising the identified
therapeutic agents, and methods of treating or preventing
age-related disorders and age-sensitive traits.
Original languageEnglish
Patent numberUS2017027139
Priority date23/08/2012
Publication statusPublished - 2-Feb-2017

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