Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof

Jan M. A. van Deursen; Darren J. Baker; James L. Kirkland; Tamara Tchkonia; Judith Campisi; Marco Demaria; Remi-Martin Laberge

Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof

Jan M. A. van Deursen (Inventor), Darren J. Baker (Inventor), James L. Kirkland (Inventor), Tamara Tchkonia (Inventor), Judith Campisi (Inventor), Marco Demaria (Inventor), Remi-Martin Laberge (Inventor)

Research output: Patent

Abstract

This disclosure provides non-human animal models for
age-related disorders and age-sensitive traits, particularly
those caused by senescence-inducing stimuli, wherein the
models comprise transgenes selectively expressed by senescent
cells. The disclosure further provides methods for
identifying therapeutic agents effective for treating or preventing
age-related disorders and age-sensitive traits using
the animal models, therapeutic agents identified using such
methods, pharmaceutical compositions comprising the identified
therapeutic agents, and methods of treating or preventing
age-related disorders and age-sensitive traits.

Original language	English
Patent number	US2017027139
Priority date	23/08/2012
Publication status	Published - 2-Feb-2017

Access to Document

https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=2017027139A1&KC=A1&FT=D&ND=3&date=20170202&DB=&locale=en_EP

Cite this

van Deursen, J. M. A., Baker, D. J., Kirkland, J. L., Tchkonia, T., Campisi, J., Demaria, M., & Laberge, R-M. (2017). Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof. (Patent No. US2017027139). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=2017027139A1&KC=A1&FT=D&ND=3&date=20170202&DB=&locale=en_EP

van Deursen, Jan M. A. (Inventor) ; Baker, Darren J. (Inventor) ; Kirkland, James L. (Inventor) ; Tchkonia, Tamara (Inventor) ; Campisi, Judith (Inventor) ; Demaria, Marco (Inventor) ; Laberge, Remi-Martin (Inventor). / Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof. Patent No.: US2017027139. Feb 02, 2017.

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title = "Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof",

abstract = "This disclosure provides non-human animal models forage-related disorders and age-sensitive traits, particularlythose caused by senescence-inducing stimuli, wherein themodels comprise transgenes selectively expressed by senescentcells. The disclosure further provides methods foridentifying therapeutic agents effective for treating or preventingage-related disorders and age-sensitive traits usingthe animal models, therapeutic agents identified using suchmethods, pharmaceutical compositions comprising the identifiedtherapeutic agents, and methods of treating or preventingage-related disorders and age-sensitive traits.",

author = "{van Deursen}, {Jan M. A.} and Baker, {Darren J.} and Kirkland, {James L.} and Tamara Tchkonia and Judith Campisi and Marco Demaria and Remi-Martin Laberge",

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van Deursen, JMA, Baker, DJ, Kirkland, JL, Tchkonia, T, Campisi, J, Demaria, M & Laberge, R-M Feb. 02 2017, Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof, Patent No. US2017027139. <https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=2017027139A1&KC=A1&FT=D&ND=3&date=20170202&DB=&locale=en_EP>

Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof. / van Deursen, Jan M. A. (Inventor); Baker, Darren J. (Inventor); Kirkland, James L. (Inventor); Tchkonia, Tamara (Inventor); Campisi, Judith (Inventor); Demaria, Marco (Inventor); Laberge, Remi-Martin (Inventor).

Patent No.: US2017027139. Feb 02, 2017.

Research output: Patent

TY - PAT

T1 - Animal models of age-related disorders and age-sensitive traits associated with senescence-inducing stimuli and uses thereof

AU - van Deursen, Jan M. A.

AU - Baker, Darren J.

AU - Kirkland, James L.

AU - Tchkonia, Tamara

AU - Campisi, Judith

AU - Demaria, Marco

AU - Laberge, Remi-Martin

PY - 2017/2/2

Y1 - 2017/2/2

N2 - This disclosure provides non-human animal models forage-related disorders and age-sensitive traits, particularlythose caused by senescence-inducing stimuli, wherein themodels comprise transgenes selectively expressed by senescentcells. The disclosure further provides methods foridentifying therapeutic agents effective for treating or preventingage-related disorders and age-sensitive traits usingthe animal models, therapeutic agents identified using suchmethods, pharmaceutical compositions comprising the identifiedtherapeutic agents, and methods of treating or preventingage-related disorders and age-sensitive traits.

AB - This disclosure provides non-human animal models forage-related disorders and age-sensitive traits, particularlythose caused by senescence-inducing stimuli, wherein themodels comprise transgenes selectively expressed by senescentcells. The disclosure further provides methods foridentifying therapeutic agents effective for treating or preventingage-related disorders and age-sensitive traits usingthe animal models, therapeutic agents identified using suchmethods, pharmaceutical compositions comprising the identifiedtherapeutic agents, and methods of treating or preventingage-related disorders and age-sensitive traits.

M3 - Patent

M1 - US2017027139

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