Animal models of excessive aggression: Implications for human aggression and violence

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Abstract

Escalated interpersonal aggression and violence are common symptoms of multiple psychiatric disorders and represent a significant global health issue. Current therapeutic strategies are limited due to a lack of understanding about the neural and molecular mechanisms underlying the 'vicious' shift of normal adaptive aggression into violence, and the environmental triggers that cause it. Development of novel animal models that validly capture the salient features of human violent actions combined with newly emerging technologies for mapping, measuring, and manipulating neuronal activity in the brain significantly advance our understanding of the etiology, neuromolecular mechanisms, and potential therapeutic interventions of excessive aggressive behaviors in humans.
Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalCurrent Opinion in Psychology
Volume19
DOIs
Publication statusPublished - Feb-2018

Keywords

  • Journal Article
  • Review
  • SOCIAL-BEHAVIOR NETWORK
  • MALE-MICE
  • NEUROBIOLOGICAL MECHANISMS
  • VENTROMEDIAL HYPOTHALAMUS
  • ESCALATED AGGRESSION
  • PREFRONTAL CORTEX
  • NERVOUS-SYSTEM
  • C-FOS
  • NEURONS
  • AMYGDALA

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