Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets

Hannah R. Wardill, Wim J. E. Tissing, Hannelouise Kissow, Andrea M. Stringer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Purpose of review

Mucositis remains a prevalent, yet poorly managed side effect of anticancer therapies. Mucositis affecting both the oral cavity and gastrointestinal tract predispose to infection and require extensive supportive management, contributing to the growing economic burden associated with cancer care. Animal models remain a critical aspect of mucositis research, providing novel insights into its pathogenesis and revealing therapeutic targets. The current review aims to provide a comprehensive overview of the current animal models used in mucositis research.

Recent findings

A wide variety of animal models of mucositis exist highlighting the highly heterogenous landscape of supportive oncology and the unique cytotoxic mechanisms of different anticancer agents. Golden Syrian hamsters remain the gold-standard species for investigation of oral mucositis induced by single dose and fractionated radiation as well as chemoradiation. There is no universally accepted gold-standard model for the study of gastrointestinal mucositis, with rats, mice, pigs and dogs all offering unique perspectives on its pathobiology.

Summary

Animal models are a critical aspect of mucositis research, providing unprecedent insight into the pathobiology of mucositis. Introduction of tumour-bearing models, cyclic dosing scheduled, concomitant agents and genetically modified animals have been integral in refining our understanding of mucositis.

Original languageEnglish
Pages (from-to)119-133
Number of pages15
JournalCurrent opinion in supportive and palliative care
Volume13
Issue number2
DOIs
Publication statusPublished - Jun-2019

Keywords

  • animal models
  • mucositis
  • pathobiology
  • preclinical
  • SMALL-INTESTINAL MUCOSITIS
  • CHEMOTHERAPY-INDUCED MUCOSITIS
  • KERATINOCYTE GROWTH-FACTOR
  • METHOTREXATE-INDUCED MUCOSITIS
  • ST-JOHNS-WORT
  • INDUCED GASTROINTESTINAL MUCOSITIS
  • STREPTOCOCCUS-THERMOPHILUS TH-4
  • IRINOTECAN-INDUCED MUCOSITIS
  • FACTOR RECEPTOR INHIBITOR
  • HAMSTER-CHEEK POUCH

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