Antibiotic prophylaxis in craniotomy: a review

Weiming Liu*, Ming Ni, Yuewei Zhang, Rob J. M. Groen

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    13 Citations (Scopus)

    Abstract

    The effectiveness of antibiotic prophylaxis (AP) in craniotomies has been clarified through the accumulation of evidence and increased antibiotic knowledge. This paper focuses on the use of AP in craniotomies during different historical periods and collects highly relevant evidence on this issue. This review surveys different AP guidelines and explains why cefazolin was selected by most guidelines. Recent prominent topics, including strategies to update and implement guidelines and antibiotic efficacy in postoperative meningitis and surveillance and decolonization therapies for methicillin-resistant Staphylococcus aureus, are discussed.

    Original languageEnglish
    Pages (from-to)407-414
    Number of pages8
    JournalNeurosurgical review
    Volume37
    Issue number3
    DOIs
    Publication statusPublished - Jul-2014

    Keywords

    • Antibiotic prophylaxis
    • Craniotomy
    • Surgical site infection
    • Guidelines
    • Cefazolin
    • RESISTANT STAPHYLOCOCCUS-AUREUS
    • RANDOMIZED CLINICAL-TRIAL
    • SURGICAL-SITE INFECTIONS
    • PLACEBO-CONTROLLED TRIAL
    • ANTIMICROBIAL PROPHYLAXIS
    • FUSIDIC ACID
    • NEUROSURGICAL PROCEDURES
    • CEREBROSPINAL-FLUID
    • WOUND INFECTIONS
    • SHUNT INFECTION

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