TY - JOUR
T1 - Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation
AU - Andreu-Sánchez, Sergio
AU - Ripoll-Cladellas, Aida
AU - Culinscaia, Anna
AU - Bulut, Ozlem
AU - Bourgonje, Arno R.
AU - Netea, Mihai G.
AU - Lansdorp, Peter
AU - Aubert, Geraldine
AU - Bonder, Marc Jan
AU - Franke, Lude H.
AU - Vogl, Thomas
AU - van der Wijst, Monique G. P.
AU - Melé, Marta
AU - van Baarle, Debbie
AU - Fu, Jingyuan
AU - Zhernakova, Alexandra
N1 - © 2024 The Authors.
PY - 2024/6/21
Y1 - 2024/6/21
N2 - Encounters with pathogens and other molecules can imprint long-lasting effects on our immune system, influencing future physiological outcomes. Given the wide range of microbes to which humans are exposed, their collective impact on health is not fully understood. To explore relations between exposures and biological aging and inflammation, we profiled an antibody-binding repertoire against 2,815 microbial, viral, and environmental peptides in a population cohort of 1,443 participants. Utilizing antibody-binding as a proxy for past exposures, we investigated their impact on biological aging, cell composition, and inflammation. Immune response against cytomegalovirus (CMV), rhinovirus, and gut bacteria relates with telomere length. Single-cell expression measurements identified an effect of CMV infection on the transcriptional landscape of subpopulations of CD8 and CD4 T-cells. This examination of the relationship between microbial exposures and biological aging and inflammation highlights a role for chronic infections (CMV and Epstein-Barr virus) and common pathogens (rhinoviruses and adenovirus C).
AB - Encounters with pathogens and other molecules can imprint long-lasting effects on our immune system, influencing future physiological outcomes. Given the wide range of microbes to which humans are exposed, their collective impact on health is not fully understood. To explore relations between exposures and biological aging and inflammation, we profiled an antibody-binding repertoire against 2,815 microbial, viral, and environmental peptides in a population cohort of 1,443 participants. Utilizing antibody-binding as a proxy for past exposures, we investigated their impact on biological aging, cell composition, and inflammation. Immune response against cytomegalovirus (CMV), rhinovirus, and gut bacteria relates with telomere length. Single-cell expression measurements identified an effect of CMV infection on the transcriptional landscape of subpopulations of CD8 and CD4 T-cells. This examination of the relationship between microbial exposures and biological aging and inflammation highlights a role for chronic infections (CMV and Epstein-Barr virus) and common pathogens (rhinoviruses and adenovirus C).
U2 - 10.1016/j.isci.2024.109981
DO - 10.1016/j.isci.2024.109981
M3 - Article
C2 - 38868191
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 6
M1 - 109981
ER -