Antibody signatures in inflammatory bowel disease: current developments and future applications

Arno R. Bourgonje*, Thomas Vogl, Eran Segal, Rinse K. Weersma

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Downloads (Pure)

Abstract

Adequate functioning of the intestinal barrier is required in order to repel invading pathogens while tolerating commensal microbiota and self-antigens. Inflammatory bowel diseases (IBD), encompassing Crohn’s disease and ulcerative colitis, are characterized by disrupted intestinal barrier integrity, resulting in excessive passage of luminal antigens and the activation of aberrant immune responses against otherwise unexposed antigens. A comprehensive overview of the exact antigens associated with IBD is still lacking, but recent innovative antibody profiling technologies have enabled systematic characterization of humoral immunity in health and disease. Here we review established serological antibodies and novel high-throughput methods, such as protein arrays, PhIP-Seq, and BCRseq, and provide an outlook on their applications in disease diagnostics, therapeutic interventions and opportunities for prevention in IBD.
Original languageEnglish
Pages (from-to)693-705
Number of pages13
JournalTRENDS IN MOLECULAR MEDICINE
Volume28
Issue number8
Early online date31-May-2022
DOIs
Publication statusPublished - Aug-2022

Cite this