Anticonvulsiva bij agressie, angststoornissen, psychotische stoornissen en alcohol- en cocaïneonttrekkingsverschijnselen

Translated title of the contribution: Anticonvulsants in the treatment of aggression, anxiety, psychosis and alcohol and cocaine withdrawal symptoms

H.G.J. Barth-Van Veldhuizen, C. Reinders, A.J.M. Loonen, W.A. Nolen

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: There is an increasing interest in the treatment of psychiatric symptoms with anticonvulsants, especially in the treatment of refractory patients. It is questionable whether or not the efficacy of anticonvulsants as psychotropic drugs is sufficiently verified. AIM: To examine the efficacy ofanticonvulsants based on the available studies. Possible indications considered are aggression, anxiety, psychosis and alcohol and cocaine withdrawal symptoms. METHOD: Relevant literature is derivedfor the period between 1966 till now from Medline, Embase, the Cochrane Library and PsycInfo, using as key words anticonvulsants, antiepileptics, carbamazepine, (sodium)valproate, valproic acid, divalproex, clonazepam, oxcarbazepine, lamotrigine, vigabatrin, topiramate, gabapentin, phenytoin, diphenylhydantoin, mental disorders, epilepsy, affective disorders and trials. RESULs: Forty-six studies were included, which explored the efficacy of carbamazepine, clonazepam, phenytoin, gabapentin and valproic acid. The efficacy of carbamazepine in the treatment of aggression and of clonazepam in the treatment of the panic disorder are sufficientty verified. The additional value of carbamazepine and valproic acidfor alcohol withdrawal is the increased rate of improvement. In the treatment of psychosis there is some evidence for the efficacy of anticonvulsants, especially as suppleraentary treatraent. CONCLUSIONS: Carbamazepine is effective in the treatment of aggression and alcohol withdrawal. Clonazepam is effective in the treatment of the panic disorder. Concerning the other applications, there are indicationsfor the efficacy of anticonvulsants. Additional research is needed to obtain more evidence for the support of these applications.
Translated title of the contributionAnticonvulsants in the treatment of aggression, anxiety, psychosis and alcohol and cocaine withdrawal symptoms
Original languageDutch
Pages (from-to)35-43
Number of pages9
JournalTijdschrift voor Psychiatrie
Issue number1
Publication statusPublished - 27-Mar-2003


  • alcohol
  • anticonvulsive agent
  • carbamazepine
  • clonazepam
  • cocaine
  • gabapentin
  • lamotrigine
  • oxcarbazepine
  • phenytoin
  • psychotropic agent
  • topiramate
  • valproate semisodium
  • valproic acid
  • vigabatrin
  • aggression
  • alcoholism
  • anxiety disorder
  • article
  • clinical trial
  • cocaine dependence
  • drug efficacy
  • epilepsy
  • human
  • mental disease
  • meta analysis
  • mood disorder
  • panic
  • psychosis
  • treatment indication
  • withdrawal syndrome

Cite this