Antimicrobial peptides and admixtures thereof showing antimicrobial activity against gram-negative pathogens

Oscar Paul Kuipers; Qian Li

Antimicrobial peptides and admixtures thereof showing antimicrobial activity against gram-negative pathogens

Oscar Paul Kuipers (Inventor), Qian Li (Inventor)

Molecular Genetics

Research output: Patent

Abstract

The invention relates to the field of medicine and microbiology, more specifically to means and methods for the treatment of infections caused by Gram-negative pathogens, in particular those showing or being prone to developing drug resistance. Provided is an admixture of (i) an inner membrane acting compound having membrane-permeating activity and/or lipid II binding activity; and (ii) one or more antimicrobial peptide(s) selected from the group consisting of RRLFRRILRWL-NH2 (GNP-6); GNNRPVYIPQPRPPHPRL (GNP-1); RIWVIWRR-NH2 (GNP-5); GIGKHVGKALKGLKGLLKGLGEC (GNP-7); and Xi X2IVQRIKKWLX3- NH2, wherein Xi is absent or K; X2 is R, K or A; and X3 is absent or R; wherein said one or more antimicrobial peptide(s) may comprise or consist of D- or L-amino acids.

Original language	English
Patent number	WO2018231058
Priority date	13/06/2017
Publication status	Published - 20-Dec-2018

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abstract = "The invention relates to the field of medicine and microbiology, more specifically to means and methods for the treatment of infections caused by Gram-negative pathogens, in particular those showing or being prone to developing drug resistance. Provided is an admixture of (i) an inner membrane acting compound having membrane-permeating activity and/or lipid II binding activity; and (ii) one or more antimicrobial peptide(s) selected from the group consisting of RRLFRRILRWL-NH2 (GNP-6); GNNRPVYIPQPRPPHPRL (GNP-1); RIWVIWRR-NH2 (GNP-5); GIGKHVGKALKGLKGLLKGLGEC (GNP-7); and Xi X2IVQRIKKWLX3- NH2, wherein Xi is absent or K; X2 is R, K or A; and X3 is absent or R; wherein said one or more antimicrobial peptide(s) may comprise or consist of D- or L-amino acids.",

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T1 - Antimicrobial peptides and admixtures thereof showing antimicrobial activity against gram-negative pathogens

AU - Kuipers, Oscar Paul

AU - Li, Qian

PY - 2018/12/20

Y1 - 2018/12/20

N2 - The invention relates to the field of medicine and microbiology, more specifically to means and methods for the treatment of infections caused by Gram-negative pathogens, in particular those showing or being prone to developing drug resistance. Provided is an admixture of (i) an inner membrane acting compound having membrane-permeating activity and/or lipid II binding activity; and (ii) one or more antimicrobial peptide(s) selected from the group consisting of RRLFRRILRWL-NH2 (GNP-6); GNNRPVYIPQPRPPHPRL (GNP-1); RIWVIWRR-NH2 (GNP-5); GIGKHVGKALKGLKGLLKGLGEC (GNP-7); and Xi X2IVQRIKKWLX3- NH2, wherein Xi is absent or K; X2 is R, K or A; and X3 is absent or R; wherein said one or more antimicrobial peptide(s) may comprise or consist of D- or L-amino acids.

AB - The invention relates to the field of medicine and microbiology, more specifically to means and methods for the treatment of infections caused by Gram-negative pathogens, in particular those showing or being prone to developing drug resistance. Provided is an admixture of (i) an inner membrane acting compound having membrane-permeating activity and/or lipid II binding activity; and (ii) one or more antimicrobial peptide(s) selected from the group consisting of RRLFRRILRWL-NH2 (GNP-6); GNNRPVYIPQPRPPHPRL (GNP-1); RIWVIWRR-NH2 (GNP-5); GIGKHVGKALKGLKGLLKGLGEC (GNP-7); and Xi X2IVQRIKKWLX3- NH2, wherein Xi is absent or K; X2 is R, K or A; and X3 is absent or R; wherein said one or more antimicrobial peptide(s) may comprise or consist of D- or L-amino acids.

M3 - Patent

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