ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES - A NEW CLASS OF AUTOANTIBODIES IN GLOMERULONEPHRITIS, VASCULITIS AND OTHER INFLAMMATORY DISORDERS

J.W.C. Tervaert; Coen Stegeman; E. BROUWER; A.H.L. MULDER; Piet Limburg; Cees Kallenberg

ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES - A NEW CLASS OF AUTOANTIBODIES IN GLOMERULONEPHRITIS, VASCULITIS AND OTHER INFLAMMATORY DISORDERS

J.W.C. Tervaert, Coen Stegeman, E. BROUWER, A.H.L. MULDER, Piet Limburg, Cees Kallenberg

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Abstract

Anti-neutrophil cytoplasmic antibodies (ANCA) constitute a new group of antibodies that are directed against myeloid proteins. Several antigens recognized by ANCA have been described. Antibodies directed to proteinase 3, myeloperoxidase and/or elastase are closely associated with necrotizing systemic vasculitis and/or necrotizing and crescentic glomerulonephritis. Changes in levels of anti-proteinase 3 in generally reflect disease activity in Wegener's granulomatosis. The diagnostic significance of other or still unknown specificities has not yet been definitely established. Recent data from in vitro and in vivo models suggest a role for ANCA in the pathogenesis of systemic vasculitides and/or necrotising and crescentic glomerulonephritis.

Original language	English
Pages (from-to)	262-272
Number of pages	11
Journal	Netherlands Journal of Medicine
Volume	45
Issue number	6
Publication status	Published - Dec-1994

Keywords

ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA)
MYELOPEROXIDASE
VASCULITIS
GLOMERULONEPHRITIS
WEGENERS GRANULOMATOSIS
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS
WEGENER GRANULOMATOSIS AUTOANTIBODIES
PRIMARY SCLEROSING CHOLANGITIS
MYELOID LYSOSOMAL-ENZYMES
CHURG-STRAUSS-SYNDROME
ACUTE-RENAL-FAILURE
ULCERATIVE-COLITIS
CRESCENTIC GLOMERULONEPHRITIS
SYSTEMIC VASCULITIS
DISEASE-ACTIVITY

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@article{149c9aff883447b1b9dbd30e768ee25a,

title = "ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES - A NEW CLASS OF AUTOANTIBODIES IN GLOMERULONEPHRITIS, VASCULITIS AND OTHER INFLAMMATORY DISORDERS",

abstract = "Anti-neutrophil cytoplasmic antibodies (ANCA) constitute a new group of antibodies that are directed against myeloid proteins. Several antigens recognized by ANCA have been described. Antibodies directed to proteinase 3, myeloperoxidase and/or elastase are closely associated with necrotizing systemic vasculitis and/or necrotizing and crescentic glomerulonephritis. Changes in levels of anti-proteinase 3 in generally reflect disease activity in Wegener's granulomatosis. The diagnostic significance of other or still unknown specificities has not yet been definitely established. Recent data from in vitro and in vivo models suggest a role for ANCA in the pathogenesis of systemic vasculitides and/or necrotising and crescentic glomerulonephritis.",

keywords = "ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA), MYELOPEROXIDASE, VASCULITIS, GLOMERULONEPHRITIS, WEGENERS GRANULOMATOSIS, RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS, WEGENER GRANULOMATOSIS AUTOANTIBODIES, PRIMARY SCLEROSING CHOLANGITIS, MYELOID LYSOSOMAL-ENZYMES, CHURG-STRAUSS-SYNDROME, ACUTE-RENAL-FAILURE, ULCERATIVE-COLITIS, CRESCENTIC GLOMERULONEPHRITIS, SYSTEMIC VASCULITIS, DISEASE-ACTIVITY",

author = "J.W.C. Tervaert and Coen Stegeman and E. BROUWER and A.H.L. MULDER and Piet Limburg and Cees Kallenberg",

note = "Article",

year = "1994",

month = dec,

language = "English",

volume = "45",

pages = "262--272",

journal = "Netherlands Journal of Medicine",

issn = "0300-2977",

publisher = "van Zuiden Communications BV.",

number = "6",

}

TY - JOUR

T1 - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES - A NEW CLASS OF AUTOANTIBODIES IN GLOMERULONEPHRITIS, VASCULITIS AND OTHER INFLAMMATORY DISORDERS

AU - Tervaert, J.W.C.

AU - Stegeman, Coen

AU - BROUWER, E.

AU - MULDER, A.H.L.

AU - Limburg, Piet

AU - Kallenberg, Cees

N1 - Article

PY - 1994/12

Y1 - 1994/12

N2 - Anti-neutrophil cytoplasmic antibodies (ANCA) constitute a new group of antibodies that are directed against myeloid proteins. Several antigens recognized by ANCA have been described. Antibodies directed to proteinase 3, myeloperoxidase and/or elastase are closely associated with necrotizing systemic vasculitis and/or necrotizing and crescentic glomerulonephritis. Changes in levels of anti-proteinase 3 in generally reflect disease activity in Wegener's granulomatosis. The diagnostic significance of other or still unknown specificities has not yet been definitely established. Recent data from in vitro and in vivo models suggest a role for ANCA in the pathogenesis of systemic vasculitides and/or necrotising and crescentic glomerulonephritis.

AB - Anti-neutrophil cytoplasmic antibodies (ANCA) constitute a new group of antibodies that are directed against myeloid proteins. Several antigens recognized by ANCA have been described. Antibodies directed to proteinase 3, myeloperoxidase and/or elastase are closely associated with necrotizing systemic vasculitis and/or necrotizing and crescentic glomerulonephritis. Changes in levels of anti-proteinase 3 in generally reflect disease activity in Wegener's granulomatosis. The diagnostic significance of other or still unknown specificities has not yet been definitely established. Recent data from in vitro and in vivo models suggest a role for ANCA in the pathogenesis of systemic vasculitides and/or necrotising and crescentic glomerulonephritis.

KW - ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA)

KW - MYELOPEROXIDASE

KW - VASCULITIS

KW - GLOMERULONEPHRITIS

KW - WEGENERS GRANULOMATOSIS

KW - RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS

KW - WEGENER GRANULOMATOSIS AUTOANTIBODIES

KW - PRIMARY SCLEROSING CHOLANGITIS

KW - MYELOID LYSOSOMAL-ENZYMES

KW - CHURG-STRAUSS-SYNDROME

KW - ACUTE-RENAL-FAILURE

KW - ULCERATIVE-COLITIS

KW - CRESCENTIC GLOMERULONEPHRITIS

KW - SYSTEMIC VASCULITIS

KW - DISEASE-ACTIVITY

M3 - Article

SN - 0300-2977

VL - 45

SP - 262

EP - 272

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

IS - 6

ER -