Anxious brain networks: A coordinate-based activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety

Jie Xu, Nicholas T. Van Dam, Chunliang Feng, Yuejia Luo, Hui Ai, Ruolei Gu, Pengfei Xu

    Research output: Contribution to journalReview articlepeer-review

    24 Citations (Scopus)

    Abstract

    Anxiety and anxiety disorders are associated with specific alterations to functional brain networks, including intra-networks and inter-networks. Given the heterogeneity within anxiety disorders and inconsistencies in functional network differences across studies, identifying common patterns of altered brain networks in anxiety is imperative. Here, we conducted an activation likelihood estimation meta-analysis of resting-state functional connectivity studies in anxiety and anxiety disorders (including 835 individuals with different levels of anxiety or anxiety disorders and 508 controls). Results show that anxiety can be characterized by hypo-connectivity of the affective network with executive control network (ECN) and default mode network (DMN), as well as de coupling of the ECN with the DMN. The connectivity within the salience network and its connectivity with sensorimotor network are also attenuated. These results reveal consistent dysregulations of affective and cognitive control related networks over networks related to emotion processing in anxiety and anxiety disorders. The current findings provide an empirical foundation for an integrated model of brain network alterations that are common across anxiety and anxiety disorders.

    Original languageEnglish
    Pages (from-to)21-30
    Number of pages10
    JournalNeuroscience and Biobehavioral Reviews
    Volume96
    DOIs
    Publication statusPublished - Jan-2019

    Keywords

    • Anxiety
    • Anxiety disorders
    • Resting-state
    • Functional brain networks
    • Activation likelihood estimation
    • Meta-analysis
    • TRANSCRANIAL MAGNETIC STIMULATION
    • VENTROMEDIAL PREFRONTAL CORTEX
    • GENERALIZED ANXIETY
    • PANIC DISORDER
    • STRUCTURAL CONNECTIVITY
    • EMOTION REGULATION
    • POSTCENTRAL-GYRUS
    • COGNITIVE CONTROL
    • DECISION-MAKING
    • NEURAL CIRCUITS

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