Apoptotic cell clearance in Systemic Lupus Erythematosus (SLE)

Esther Reefman

Research output: ThesisThesis fully internal (DIV)

1313 Downloads (Pure)


Systemic lupus erythematosus (SLE) is an incurable multi-organ autoimmune disease characterized by a wide array of clinical manifestations, ranging from skin and mucosal lesions to severe injuries in the central nervous system, kidneys and other organs. The disease primarily affects women in their reproductive years, and its prevalence is estimated to vary between 12 and 64 cases per 100,000 in Europeanderived populations and to be higher in non-European-derived populations (1). The presence of autoantibodies directed against a set of intracellular constituents classifies SLE as an autoimmune disease. In fact, autoantibodies to nuclear and cytoplasmic components, can be present years before the diagnosis of SLE and progressive accumulation frequently precedes the onset of the disease.
Original languageEnglish
QualificationDoctor of Philosophy
  • Kallenberg, Cornelis, Supervisor
  • Limburg, Pieter, Supervisor
Print ISBNs903672838X, 9036728371
Publication statusPublished - 2006


  • Lupus erythematodes disseminatus, Celdood
  • immunologische ziekten

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