Applicability of equine hydroxyapatite collagen (eHAC) bone blocks for lateral augmentation of the alveolar crest. A histological and histomorphometric analysis in rats

P. J. Zecha*, J. Schortinghuis, J. E. van der Wal, H. Nagursky, K. C. van den Broek, S. Sauerbier, A. Vissink, G. M. Raghoebar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

This study assessed the mechanical characteristics, biocompatibility and osteoconductive properties of an equine hydroxyapatite collagen (eHAC) bone block when applied as a bone substitute for lateral augmentation of rat mandible. 96 rats underwent lateral augmentation of the mandible, using two substitute bone blocks (eHAC or Bio-Oss (R) spongiosa) or autologous bone grafts. Signs of inflammation, amount of bone formation and ingrowth of bone into the bone blocks were assessed at 1 and 3 months. eHAC blocks were mechanically rigid and could be fixed firmly and easily. Bio-Oss (R) spongiosa blocks were brittle and fixation was difficult. eHAC and Bio-Oss (R) spongiosa blocks were biocompatible and induced few or no signs of inflammation. Inflammation prevalence between the groups was not statistically different. Bone formation and bone growth into the blocks was significantly higher in MAC than Bio-Oss (R) spongiosa blocks, but lower than in autologous bone grafts (after 1 and 3 months). Regression analysis showed that the autologous bone graft predicted new bone formation at both time points. The eHAC block was only a predictor at I month; a trend was found at 3 months. The application of biodegradable membranes was not related to more bone ingrowth.

Original languageEnglish
Pages (from-to)533-542
Number of pages10
JournalInternational Journal of Oral and Maxillofacial Surgery
Volume40
Issue number5
DOIs
Publication statusPublished - May-2011

Keywords

  • lateral augmentation
  • alveolar crest
  • eHAC
  • Bio-Oss (R)
  • bone graft
  • TRICALCIUM PHOSPHATE BLOCKS
  • ANORGANIC BOVINE BONE
  • RIDGE AUGMENTATION
  • SINUS AUGMENTATION
  • BARRIER MEMBRANES
  • AUTOLOGOUS BONE
  • FIBRIN GLUE
  • BIO-OSS(R)
  • GRAFTS
  • MORBIDITY

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