Applications of stable isotopes in clinical pharmacology

Reinout C A Schellekens; Frans Stellaard; Herman J Woerdenbag; Henderik W Frijlink; Jos G W Kosterink

doi:10.1111/j.1365-2125.2011.04071.x

Applications of stable isotopes in clinical pharmacology

Reinout C A Schellekens, Frans Stellaard, Herman J Woerdenbag, Henderik W Frijlink, Jos G W Kosterink

Research output: Contribution to journal › Article › Academic › peer-review

61 Citations (Scopus)

Abstract

This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans.

Original language	English
Pages (from-to)	879-897
Number of pages	19
Journal	British Journal of Clinical Pharmacology
Volume	72
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2125.2011.04071.x
Publication status	Published - Dec-2011

Keywords

Bioavailability
Breath test
Clinical pharmacology
Pharmacokinetics
Phenotyping
Stable isotope
acecainide
carbamazepine
carbon
cibenzoline
flecainide
gallopamil
glyceryl trinitrate
hydrogen
ibuprofen
imipramine
indinavir
isotope
mefloquine
methadone
metoprolol
mirtazapine
moracizine
nicotine
nifedipine
nitrendipine
nitrogen
oxygen
phenytoin
propantheline bromide
terbutaline
terodiline
testosterone
trazodone
unindexed drug
verapamil
adult
bioavailability
case report
clinical pharmacology
drug binding
drug bioavailability
drug delivery system
drug metabolism
drug release
drug safety
human
physical chemistry
priority journal
review

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61 Citations
1 Erratum

Erratum: Applications of stable isotopes in clinical pharmacology (vol 72, pg 879, 2011)
Schellekens, R. C. A., Stellaard, F., Woerdenbag, H. J., Frijlink, H. W. & Kosterink, J. G. W., Apr-2013, In: British Journal of Clinical Pharmacology. 75, 4, p. 1171 1 p.
Research output: Contribution to journal › Erratum

Cite this

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abstract = "This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans.",

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author = "Schellekens, {Reinout C A} and Frans Stellaard and Woerdenbag, {Herman J} and Frijlink, {Henderik W} and Kosterink, {Jos G W}",

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ER -

Applications of stable isotopes in clinical pharmacology

Abstract

Keywords

Access to Document

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Research output

Erratum: Applications of stable isotopes in clinical pharmacology (vol 72, pg 879, 2011)

Cite this