Applying broadband terahertz time‐domain spectroscopy to the analysis of crystalline proteins: A dehydration study

Kasia Tych, Andrew D. Burnett, Christopher D. Wood, John E. Cunningham, Arwen R. Pearson, A.G. Davies, Edmund H. Linfield*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

The application of terahertz time‐domain spectroscopy and imaging to the study of proteins in crystalline form is demonstrated. Terahertz time‐domain spectroscopy is particularly sensitive to the long‐range ordering of molecules, with proven utility for the spectroscopy of crystalline biological small molecules. Here, the terahertz time‐domain absorption response of a macromolecular protein single crystal is investigated for the first time. In particular, the effect of dehydration on the terahertz absorption coefficient of tetragonal hen egg white lysozyme crystals is reported.
Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalJournal of Applied Crystallography
Volume44
Issue number1
DOIs
Publication statusPublished - Feb-2011
Externally publishedYes

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