Approaches to drug resistance in solid tumors: with emphasis on lung cancer

Marleen Bakker

Research output: ThesisThesis fully internal (DIV)

753 Downloads (Pure)


De novo or acquired resistance of tumor cells to anticancer agents remains a major problem for the therapeutic efficacy of chemotherapeutic drugs. Most solid tumors are intrinsically insensitive or acquire resistance after initial response to chemotherapy. Different mechanisms seem to play a role in drug resistance such as the overexpression of membrane efflux pumps, a decrease in the activity of target enzymes, and an increase in cellular detoxifying and DNA repair capacity. ... Zie: Summary
Original languageEnglish
QualificationDoctor of Philosophy
  • Mulder, H.M., Supervisor, External person
  • Koëter, G.H., Supervisor
  • de Vries, Liesbeth, Supervisor
Print ISBNs9036709210
Publication statusPublished - 2005


  • Proefschriften (vorm)
  • Anthracyclinen
  • Longkanker, Geneesmiddelenresistentie,
  • farmacologie (geneeskunde);

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