Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?

Naishi Li, Jingyuan Fu, Debby P. Koonen, Jan Albert Kuivenhoven, Harold Snieder, Marten H. Hofker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the current dominant paradigm is that insulin resistance leads to dyslipidemia. However, dyslipidemia may also cause insulin resistance; this was postulated 30 years ago, but has never been substantiated. Establishing whether dyslipidemia plays a causal role in the etiology of insulin resistance is important since it could reveal new avenues for combating type 2 diabetes. In this review we summarize recent evidence from epidemiological, genetic and intervention studies to re-address this old hypothesis.

Original languageEnglish
Pages (from-to)130-138
Number of pages9
JournalATHEROSCLEROSIS
Volume233
Issue number1
DOIs
Publication statusPublished - Mar-2014

Keywords

  • HDL-cholesterol
  • Triglycerides
  • Insulin resistance
  • Dyslipidemia
  • TYPE-2 DIABETES-MELLITUS
  • HEPATIC LIPASE GENE
  • FATTY LIVER-DISEASE
  • IMPAIRED GLUCOSE-TOLERANCE
  • CORONARY-ARTERY-DISEASE
  • LIFE-STYLE INTERVENTION
  • BETA-CELL FUNCTION
  • LIPOPROTEIN-LIPASE
  • METABOLIC SYNDROME
  • FOLLOW-UP

Cite this