Arterial inflammation in young patients with human immunodeficiency virus infection: A cross-sectional study using F-18 FDG PET/CT

Ismaheel O. Lawal, Alfred O. Ankrah, Gbenga O. Popoola, Thabo Lengana, Mike M. Sathekge*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    11 Citations (Scopus)

    Abstract

    Background

    HIV infection is associated with the risk of development of atherosclerosis at a younger age. We compared arterial inflammation in HIV-infected and HIV-uninfected patients with otherwise low-risk factors for cardiovascular disease (CVD) using FDG PET/CT.

    Methods

    242 patients aged 18-40 years with low-risk factors for CVD consisting of 121 HIV-infected patients and 121 HIV-uninfected age- and gender-matched controls were studied, mean age=34.955.46 years. We calculated and compared the target-to-background ratio of FDG uptake in ascending aorta of HIV-infected and non-infected patients.

    Results

    Median CD4 count and viral load were 375.5 cells/mm(3) (range 2-1094) and 6391.00 copies/mL (range 24-1,348,622), respectively. There was slightly higher but significant overlap in the TBR between HIV-infected group compared with control (1.22, 0.87-2.02 vs. 1.12, 0.38-1.40, P

    Conclusion

    Marginally higher TBR with a significant overlap exist in HIV-infected patients compared with control. Arterial F-18 FDG uptake is not affected by the CD 4 count, viral load, gender, or duration of HIV infection.

    Original languageEnglish
    Pages (from-to)1258-1265
    Number of pages8
    JournalJournal of Nuclear Cardiology
    Volume26
    Issue number4
    DOIs
    Publication statusPublished - Aug-2019

    Keywords

    • FDG
    • PET
    • CT
    • HIV
    • inflammation
    • cardiovascular disease
    • HIV-INFECTION
    • DISEASE
    • RISK
    • THERAPY
    • TIME

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