Abstract
The invention relates to the field of nanopores and the use thereof in analyzing biopolymers, including polypeptides and polynucleotides. Provided is an artificial nanopore comprising a multimeric assembly of subunits, each subunit comprising (i) the transmembrane (TM) sequence of a β-barrel or α-helical pore forming protein fused to the amino acid sequence of (ii) a subunit of a ring-forming protein capable of controlling the transport of a polypeptide or polynucleotide across the TM region of the assembly.
| Original language | English |
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| Patent number | WO2021101378 |
| Priority date | 19/11/2019 |
| Filing date | 19/11/2020 |
| Publication status | Published - 27-May-2021 |