Assessing Differences in Articulatory-Acoustic Vowel Space in Parkinson’s Disease by Sex and Phenotype

Nikki Hoekzema, Teja Rebernik*, Thomas Tienkamp, Sasha Chaboksavar, Valentina Ciot, Annetje Gleichman, Roel Jonkers, Aude Noiray, Martijn Wieling, Defne Abur

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


The goal of this study was to determine whether articulatoryacoustics differ between individuals in the tremor-dominant (TD) and postural instability/gait difficulty (PIGD) phenotypes of Parkinson's disease (PD). The study included 31 individuals with PD (21 TD, 10 PIGD) and 29 control speakers (CS) who were all Dutch native speakers. A read speech task and a semi-spontaneous speech task were completed, and the Articulatory-Acoustic Vowel Space (AAVS) was calculated for both tasks. Results showed no significant difference in AAVS between the overall control group and PD for either phenotype. Follow-up analyses, pooling speech data from our prior study (+27 PD, +23 CS), demonstrated a significantly lower AAVS in males with PD compared to controls and no group differences for females. Thus, articulatory-acoustic changes may be more pronounced for male compared to female speakers with PD, but may not differ by PD phenotype.
Original languageEnglish
Title of host publicationProceedings of the 13th International Seminar on Speech Production
Publication statusPublished - 2024
Event13th International Seminar of Speech Production - Autrans, France
Duration: 13-May-202417-May-2024


Conference13th International Seminar of Speech Production
Abbreviated titleISSP 2024


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