Association between blood eosinophil counts and risk of rehospitalization in patients with asthma

Marjan Kerkhof, Trung N. Tran, Maarten van den Berge, Guy Brusselle, Gokul Gopalan, Rupert Jones, JanWillem Kocks, Andrew Menzies-Gow, Javier Nuevo, Ian Pavord, Sarang Rastogi, David Price

Research output: Contribution to journalMeeting AbstractAcademic

Abstract

Introduction: A United Kingdom study (Lancet Respir Med. 2015;3:849–58) demonstrated a greater risk of asthma exacerbations with high blood eosinophil counts (BEC).

Aims and Objectives: We aimed to determine if patients hospitalized for asthma exacerbations were more likely to be readmitted if they had high BEC before admission.

Methods: We analyzed 2 years of medical records data (Clinical Practice Research Datalink with Hospital Episode Statistics Linkage) from patients (aged ≥5 years) hospitalized for asthma who had BECs recorded within 1 year before admission. Patients were characterized in a baseline year, prior to the most recent first hospitalization for asthma (index date) occurring within 1 year after a BEC recording. We analyzed the association between high BEC (≥0.35 x 109/L) and readmission risk during 1 year of follow-up after index date, with adjustment for age, sex, smoking, and timing of most recent BEC as confounders.

Results: A total of 835 of 2,613 patients with asthma (32%) had high BEC. In addition, 130 (55 with high BEC) patients were rehospitalized for asthma during the follow-up year. Patients with prior high BEC had a greater risk (6.6% vs. 4.2%; p=0.009) and a greater hazard ratio (HR: 1.45; 95% CI: 1.02−2.08; p=0.040) of readmission than those without high BEC. The association was strongest for nonsmokers (HR: 1.95; 95% CI: 1.16−3.31; p=0.013), compared with ex-smokers (HR: 1.52; 95% CI: 0.74−3.10; p=0.253) and with current smokers (HR: 0.97; 95% CI: 0.48–1.97; p=0.936).

Conclusions: Patients with asthma and preadmission high BEC have a greater risk of rehospitalization for exacerbations.
Original languageEnglish
Number of pages1
JournalEuropean Respiratory Journal
Volume50
DOIs
Publication statusPublished - 1-Sep-2017
EventEuropean-Respiratory-Society (ERS) International Congress - Milan, Italy
Duration: 9-Sep-201713-Sep-2017
http://erscongress.org/home-2014.html

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