Association between Escherichia coli bacteriuria and renal function in women - Long-term follow-up

Ruby Meiland, Ronald P. Stolk, Suzanne E. Geerlings*, Petra H. M. Peeters, Diederick E. Grobbee, Frank E. J. Coenjaerts, Ellen C. Brouwer, Andy I. M. Hoepelman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: We sought to investigate whether Escherichia coli bacteriuria is associated with a decline in renal function or with the development of end-stage renal failure after long-term follow-up.

Methods: We performed a full cohort analysis for women who participated in 2 population-based studies. The baseline cohort consisted of women who collected morning midstream urine samples that were stored. In the cohort study, the presence of E coli bacteriuria was subsequently determined by real-time polymerase chain reaction. After a mean +/- SD follow-up of 11.5 +/- 1.7 years, blood samples were drawn from 490 women. In the nested case-control study, cases comprised all women who underwent kidney therapy (hemodialysis or renal transplantation) between participation in the baseline cohort study and a mean +/- SD of 13.8 +/- 7.4 years later.

Results: Themean +/- SD age at baseline was 45.0 +/- 3.2 years, and 48 women(10%) had E coli bacteriuria. After 11.5 years, the mean +/- SD creatinine clearance (Cockroft-Gault formula) was similar between the 2 groups (87 +/- 21 mL/min [1.5 +/- 0.4 mL/s] and 85 +/- 18mL/min [1.4 +/- 0.3 mL/s] for women who had and those who did not have bacteriuria, respectively). In the nested case-control study, the prevalence of E coli bacteriuria was 14% among cases and control subjects. The odds ratio corrected for age for the development of end-stage renal failure in the presence of E coli bacteriuria at baseline was 1.1 (95% confidence interval, 0.4-2.8; P=. 86).

Conclusion: Escherichia coli bacteriuria is not associated with a decline in renal function or with the development of end-stage renal failure in a population of generally healthy women during 12 to 14 years of follow-up.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalArchives of Internal Medicine
Volume167
Issue number3
Publication statusPublished - 12-Feb-2007

Keywords

  • URINARY-TRACT-INFECTION
  • ASYMPTOMATIC BACTERIURIA
  • RISK-FACTORS
  • PYELONEPHRITIS
  • POPULATION
  • GUIDELINES
  • CHILDHOOD
  • UTRECHT
  • CANCER
  • COHORT

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