Association between nonspecific bronchial hyperreactivity and superoxide anion production by polymorphonuclear leukocytes in chronic airflow obstruction

T.E.J Renkema*, D.S Postma, J.A Noordhoek, H.J Sluiter, H.F Kauffman

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

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    Inflammatory reactions are believed to be important in nonspecific bronchial hyperreactivity (BHR). To investigate the potential role for oxidant-mediated modulation of BHR, we investigated oxidative metabolism of polymorphonuclear leukocytes (PMN) from the peripheral blood in 28 nonallergic patients with chronic airflow obstruction (CAO). No difference in O −2 generation was found between 14 smokers and 14 ex-smokers with CAO. A significant correlation was found between the degree of BHR and O −2 generation of PMN after stimulation with 20 ng/ml phorbol myristate acetate, both in smokers (r=0.59,p<0.01) and in ex-smokers (r=0.79,p<0.01). The results suggest that oxygen radicals in a direct or indirect way may modulate BHR. Thus, in nonallergic patients with CAO, BHR and inflammation may be linked in a similar way as in allergic patients with asthma
    Original languageEnglish
    Pages (from-to)52-54
    Number of pages3
    JournalAgents and actions
    Issue number1-2
    Publication statusPublished - Jan-1989

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