Association Between Statin Use and Cardiovascular Mortality at the Population Level: An Ecologic Study

Maarten J. Bijlsma*, Fanny Janssen, Jens Bos, Pieter W. Kamphuisen, Stijn Vansteelandt, Eelko Hak

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
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Abstract

Background: We assessed the contribution of statin use to the decline in cardiovascular mortality for The Netherlands over the period 1994-2010.

Methods: We combined aggregated mortality data from Statistics Netherlands with dispensing data from a representative drug dispensing database. We estimated mortality as if prevalence of statin use had remained at its observed 1994 levels throughout the period 1994-2010 for acute myocardial infarction, other ischemic heart disease, and cerebrovascular disease using Poisson models adjusted for various confounders.

Results: We estimated that keeping prevalence of statin use at observed 1994 levels would have resulted in 6.3 (95% confidence interval [CI] = 4.9, 7.8), 1.6 (95% CI = 0.8, 2.6), and 3.4 (95% CI = 2.2, 4.6) more acute myocardial infarction, ischemic heart disease, and cerebrovascular deaths per 10,000 person-years, respectively.

Conclusion: The findings indicate that statin therapy was associated with decreasing national cardiovascular mortality rates in the period 1994 to 2010.

Original languageEnglish
Pages (from-to)802-805
Number of pages4
JournalEpidemiology
Volume26
Issue number6
DOIs
Publication statusPublished - Nov-2015

Keywords

  • MYOCARDIAL-INFARCTION
  • HEART-DISEASE
  • BIRTH COHORT
  • RISK-FACTORS
  • TRENDS
  • OUTCOMES
  • THERAPY
  • EXPLANATION
  • SMOKING
  • TRIAL

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