Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study

Sabrina Abou Kamar; Valentina Bracun; Maissa El-Qendouci; Nils Bomer; Stephan J.L. Bakker; Ron T. Gansevoort; Eric Boersma; Isabella Kardys; Rudolf A. de Boer; Navin Suthahar

doi:10.1002/ejhf.3328

Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study

Sabrina Abou Kamar, Valentina Bracun, Maissa El-Qendouci, Nils Bomer, Stephan J.L. Bakker, Ron T. Gansevoort, Eric Boersma, Isabella Kardys, Rudolf A. de Boer^*, Navin Suthahar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aim: Senescence is a major risk factor for heart failure (HF), and insulin-like growth factor-binding protein-7 (IGFBP7) has been identified as an important senescence-inducing factor. The aim of this study was to examine the value of baseline and repeat IGFBP7 measurements in predicting future HF among community-dwelling Dutch adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study.

Methods and results: Individuals without prevalent HF who attended PREVEND visits 2 and 4 median of 5.1 years apart (25th–75th percentile, 4.9–5.2) with measurements of IGFBP7 were included. We used Cox proportional hazards models to investigate the association between IGFBP7 and HF incidence. A total of 6125 participants attending visit 2 (mean ± standard deviation [SD] age 53.1 ± 12.2 years; 3151 [51.4%] men) were followed for a median of 8.4 (7.8–8.9) years, and 194 participants (3.2%) developed incident HF. Median baseline IGFBP7 concentration was 87.0 (75.1–97.3) ng/ml, and baseline IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted hazard ratio [HR] per 1 SD change in log-transformed IGFBP7: 1.22, 95% confidence interval [CI] 1.03–1.46). Baseline IGFBP7 was also significantly associated with incident HF in individuals with N-terminal pro-B-type natriuretic peptide <125 ng/L. Among 3879 participants attending both visits 2 and 4 (mean ± SD age 57.5 ± 11.3 years; 1952 [50.3%] men), 93 individuals developed HF (after visit 4) during a median follow-up of 3.2 (2.8–3.9) years. Median increase in IGFBP7 concentration between visits was 0.68 (−7.09 to 8.36) ng/ml, and changes in IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted HR per 1 SD change in log-transformed IGFBP7: 1.68, 95% CI 1.19–2.36).

Conclusions: Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.

Original language	English
Number of pages	9
Journal	European Journal of Heart Failure
DOIs	https://doi.org/10.1002/ejhf.3328
Publication status	Accepted/In press - 17-Jul-2024

Keywords

General population
IGFBP7
Incident heart failure
Senescence

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Association of baseline and longitudinalchanges in insulin-like growth factor-bindingprotein-7 with the risk of incident heart failure-Data from the PREVEND studyFinal publisher's version, 570 KBLicence: CC BY-NC

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Abou Kamar, S., Bracun, V., El-Qendouci, M., Bomer, N., Bakker, S. J. L., Gansevoort, R. T., Boersma, E., Kardys, I., de Boer, R. A., & Suthahar, N. (Accepted/In press). Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.3328

@article{f04cebd763bf44a6a70fdedff4e7c113,

title = "Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study",

abstract = "Aim: Senescence is a major risk factor for heart failure (HF), and insulin-like growth factor-binding protein-7 (IGFBP7) has been identified as an important senescence-inducing factor. The aim of this study was to examine the value of baseline and repeat IGFBP7 measurements in predicting future HF among community-dwelling Dutch adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study. Methods and results: Individuals without prevalent HF who attended PREVEND visits 2 and 4 median of 5.1 years apart (25th–75th percentile, 4.9–5.2) with measurements of IGFBP7 were included. We used Cox proportional hazards models to investigate the association between IGFBP7 and HF incidence. A total of 6125 participants attending visit 2 (mean ± standard deviation [SD] age 53.1 ± 12.2 years; 3151 [51.4%] men) were followed for a median of 8.4 (7.8–8.9) years, and 194 participants (3.2%) developed incident HF. Median baseline IGFBP7 concentration was 87.0 (75.1–97.3) ng/ml, and baseline IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted hazard ratio [HR] per 1 SD change in log-transformed IGFBP7: 1.22, 95% confidence interval [CI] 1.03–1.46). Baseline IGFBP7 was also significantly associated with incident HF in individuals with N-terminal pro-B-type natriuretic peptide <125 ng/L. Among 3879 participants attending both visits 2 and 4 (mean ± SD age 57.5 ± 11.3 years; 1952 [50.3%] men), 93 individuals developed HF (after visit 4) during a median follow-up of 3.2 (2.8–3.9) years. Median increase in IGFBP7 concentration between visits was 0.68 (−7.09 to 8.36) ng/ml, and changes in IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted HR per 1 SD change in log-transformed IGFBP7: 1.68, 95% CI 1.19–2.36). Conclusions: Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.",

keywords = "General population, IGFBP7, Incident heart failure, Senescence",

author = "{Abou Kamar}, Sabrina and Valentina Bracun and Maissa El-Qendouci and Nils Bomer and Bakker, {Stephan J.L.} and Gansevoort, {Ron T.} and Eric Boersma and Isabella Kardys and {de Boer}, {Rudolf A.} and Navin Suthahar",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",

year = "2024",

month = jul,

day = "17",

doi = "10.1002/ejhf.3328",

language = "English",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Wiley",

}

Abou Kamar, S, Bracun, V, El-Qendouci, M, Bomer, N , Bakker, SJL , Gansevoort, RT, Boersma, E, Kardys, I, de Boer, RA & Suthahar, N 2024, 'Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study', European Journal of Heart Failure. https://doi.org/10.1002/ejhf.3328

TY - JOUR

T1 - Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure

T2 - Data from the PREVEND study

AU - Abou Kamar, Sabrina

AU - Bracun, Valentina

AU - El-Qendouci, Maissa

AU - Bomer, Nils

AU - Bakker, Stephan J.L.

AU - Gansevoort, Ron T.

AU - Boersma, Eric

AU - Kardys, Isabella

AU - de Boer, Rudolf A.

AU - Suthahar, Navin

PY - 2024/7/17

Y1 - 2024/7/17

N2 - Aim: Senescence is a major risk factor for heart failure (HF), and insulin-like growth factor-binding protein-7 (IGFBP7) has been identified as an important senescence-inducing factor. The aim of this study was to examine the value of baseline and repeat IGFBP7 measurements in predicting future HF among community-dwelling Dutch adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study. Methods and results: Individuals without prevalent HF who attended PREVEND visits 2 and 4 median of 5.1 years apart (25th–75th percentile, 4.9–5.2) with measurements of IGFBP7 were included. We used Cox proportional hazards models to investigate the association between IGFBP7 and HF incidence. A total of 6125 participants attending visit 2 (mean ± standard deviation [SD] age 53.1 ± 12.2 years; 3151 [51.4%] men) were followed for a median of 8.4 (7.8–8.9) years, and 194 participants (3.2%) developed incident HF. Median baseline IGFBP7 concentration was 87.0 (75.1–97.3) ng/ml, and baseline IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted hazard ratio [HR] per 1 SD change in log-transformed IGFBP7: 1.22, 95% confidence interval [CI] 1.03–1.46). Baseline IGFBP7 was also significantly associated with incident HF in individuals with N-terminal pro-B-type natriuretic peptide <125 ng/L. Among 3879 participants attending both visits 2 and 4 (mean ± SD age 57.5 ± 11.3 years; 1952 [50.3%] men), 93 individuals developed HF (after visit 4) during a median follow-up of 3.2 (2.8–3.9) years. Median increase in IGFBP7 concentration between visits was 0.68 (−7.09 to 8.36) ng/ml, and changes in IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted HR per 1 SD change in log-transformed IGFBP7: 1.68, 95% CI 1.19–2.36). Conclusions: Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.

AB - Aim: Senescence is a major risk factor for heart failure (HF), and insulin-like growth factor-binding protein-7 (IGFBP7) has been identified as an important senescence-inducing factor. The aim of this study was to examine the value of baseline and repeat IGFBP7 measurements in predicting future HF among community-dwelling Dutch adults from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study. Methods and results: Individuals without prevalent HF who attended PREVEND visits 2 and 4 median of 5.1 years apart (25th–75th percentile, 4.9–5.2) with measurements of IGFBP7 were included. We used Cox proportional hazards models to investigate the association between IGFBP7 and HF incidence. A total of 6125 participants attending visit 2 (mean ± standard deviation [SD] age 53.1 ± 12.2 years; 3151 [51.4%] men) were followed for a median of 8.4 (7.8–8.9) years, and 194 participants (3.2%) developed incident HF. Median baseline IGFBP7 concentration was 87.0 (75.1–97.3) ng/ml, and baseline IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted hazard ratio [HR] per 1 SD change in log-transformed IGFBP7: 1.22, 95% confidence interval [CI] 1.03–1.46). Baseline IGFBP7 was also significantly associated with incident HF in individuals with N-terminal pro-B-type natriuretic peptide <125 ng/L. Among 3879 participants attending both visits 2 and 4 (mean ± SD age 57.5 ± 11.3 years; 1952 [50.3%] men), 93 individuals developed HF (after visit 4) during a median follow-up of 3.2 (2.8–3.9) years. Median increase in IGFBP7 concentration between visits was 0.68 (−7.09 to 8.36) ng/ml, and changes in IGFBP7 levels were significantly associated with risk for incident HF (HF risk factors adjusted HR per 1 SD change in log-transformed IGFBP7: 1.68, 95% CI 1.19–2.36). Conclusions: Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.

KW - General population

KW - IGFBP7

KW - Incident heart failure

KW - Senescence

UR - http://www.scopus.com/inward/record.url?scp=85198733631&partnerID=8YFLogxK

U2 - 10.1002/ejhf.3328

DO - 10.1002/ejhf.3328

M3 - Article

AN - SCOPUS:85198733631

SN - 1388-9842

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

ER -

Association of baseline and longitudinal changes in insulin-like growth factor-binding protein-7 with the risk of incident heart failure: Data from the PREVEND study

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