Association of COMT gene polymorphisms with Parkinson's disease

S. A. Ivanova; V. M. Alifirova; I. A. Zhukova; V. V. Tiguntsev; I. Pozhidaev; D. Z. Osmanova; O. Yu Fedorenko; M. B. Freydin; Yu. S. Mironova; N. G. Zhukova; N. A. Bokhan; A. J. M. Loonen

doi:10.20538/1682-0363-2017-3-70-78

Association of COMT gene polymorphisms with Parkinson's disease

S. A. Ivanova^*, V. M. Alifirova, I. A. Zhukova, V. V. Tiguntsev, I. Pozhidaev, D. Z. Osmanova, O. Yu Fedorenko, M. B. Freydin, Yu. S. Mironova, N. G. Zhukova, N. A. Bokhan, A. J. M. Loonen

^*Corresponding author for this work

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Abstract

Parkinson's disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.

The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson's disease.

Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.

Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson's disease.

Original language	Russian
Pages (from-to)	70-78
Number of pages	9
Journal	Byulleten sibirskoy meditsiny
Volume	16
Issue number	3
DOIs	https://doi.org/10.20538/1682-0363-2017-3-70-78
Publication status	Published - 2017

Keywords

Parkinson's disease
single nucleotide polymorphisms
COMT gene
CATECHOL-O-METHYLTRANSFERASE
SUSCEPTIBILITY
RISK
EPIDEMIOLOGY
METAANALYSIS
POPULATION
SCALE
DRD2

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title = "Association of COMT gene polymorphisms with Parkinson's disease",

abstract = "Parkinson's disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson's disease.Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson's disease.",

keywords = "Parkinson's disease, single nucleotide polymorphisms, COMT gene, CATECHOL-O-METHYLTRANSFERASE, SUSCEPTIBILITY, RISK, EPIDEMIOLOGY, METAANALYSIS, POPULATION, SCALE, DRD2",

author = "Ivanova, \{S. A.\} and Alifirova, \{V. M.\} and Zhukova, \{I. A.\} and Tiguntsev, \{V. V.\} and I. Pozhidaev and Osmanova, \{D. Z.\} and Fedorenko, \{O. Yu\} and Freydin, \{M. B.\} and Mironova, \{Yu. S.\} and Zhukova, \{N. G.\} and Bokhan, \{N. A.\} and Loonen, \{A. J. M.\}",

year = "2017",

doi = "10.20538/1682-0363-2017-3-70-78",

language = "Russian",

volume = "16",

pages = "70--78",

journal = "Byulleten sibirskoy meditsiny",

issn = "1682-0363",

publisher = "SIBERIAN STATE MEDICAL UNIV",

number = "3",

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TY - JOUR

T1 - Association of COMT gene polymorphisms with Parkinson's disease

AU - Ivanova, S. A.

AU - Alifirova, V. M.

AU - Zhukova, I. A.

AU - Tiguntsev, V. V.

AU - Pozhidaev, I.

AU - Osmanova, D. Z.

AU - Fedorenko, O. Yu

AU - Freydin, M. B.

AU - Mironova, Yu. S.

AU - Zhukova, N. G.

AU - Bokhan, N. A.

AU - Loonen, A. J. M.

PY - 2017

Y1 - 2017

N2 - Parkinson's disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson's disease.Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson's disease.

AB - Parkinson's disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson's disease.Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson's disease.

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KW - COMT gene

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KW - SUSCEPTIBILITY

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KW - EPIDEMIOLOGY

KW - METAANALYSIS

KW - POPULATION

KW - SCALE

KW - DRD2

U2 - 10.20538/1682-0363-2017-3-70-78

DO - 10.20538/1682-0363-2017-3-70-78

M3 - Article

SN - 1682-0363

VL - 16

SP - 70

EP - 78

JO - Byulleten sibirskoy meditsiny

JF - Byulleten sibirskoy meditsiny

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