Association of depressive disorders, depression characteristics and antidepressant medication with inflammation

N. Vogelzangs*, H. E. Duivis, A.T.F. Beekman, C. Kluft, J. Neuteboom, W. Hoogendijk, Johannes H. Smit, P. de Jonge, Brenda Penninx

*Corresponding author for this work

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202 Citations (Scopus)
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Abstract

Growing evidence suggests that immune dysregulation may be involved in depressive disorders, but the exact nature of this association is still unknown and may be restricted to specific subgroups. This study examines the association between depressive disorders, depression characteristics and antidepressant medication with inflammation in a large cohort of controls and depressed persons, taking possible sex differences and important confounding factors into account. Persons (18-65 years) with a current (N = 1132) or remitted (N = 789) depressive disorder according to DSM-IV criteria and healthy controls (N = 494) were selected from the Netherlands Study of Depression and Anxiety. Assessments included clinical characteristics (severity, duration and age of onset), use of antidepressant medication and inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)). After adjustment for sociodemographics, currently depressed men, but not women, had higher levels of CRP (1.33 versus 0.92 mg l(-1), P

Original languageEnglish
Article numbere79
Number of pages9
JournalTranslational Psychiatry
Volume2
DOIs
Publication statusPublished - 21-Feb-2012

Keywords

  • antidepressants
  • cohort study
  • depression characteristics
  • depressive disorder
  • inflammation
  • C-REACTIVE PROTEIN
  • PITUITARY-ADRENAL AXIS
  • HEART-RATE-VARIABILITY
  • MAJOR DEPRESSION
  • TREATMENT RESPONSE
  • METABOLIC SYNDROME
  • HEALTH BEHAVIORS
  • SEX-DIFFERENCES
  • ANXIETY NESDA
  • CYTOKINES

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