Association of family risk and lifestyle/comorbidities in ovarian cancer patients

Natalia Teixeira*, Maria Aparecida Azevedo Koike Folgueira, Simone Maistro, Giselly Encinas, Geertruida Hendrika de Bock, Maria Del Pilar Estevez Diz

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objectives: to analyze factors that might indicate familial predisposition for ovarian cancer in patients diagnosed with this disease.

Methods: in a prospective single center cohort study at the Institute of Cancer of the State of Sao Paulo (ICESP), 51 women diagnosed with ovarian cancer were included. Familial predisposition for ovarian cancer was defined as having a higher than 10% chance of having a BRCA1/2 mutation according to the Manchester scoring system, a validated method to assess the likelihood of mutation detection. Each patient was interviewed with a standardized questionnaire on established risk factors for ovarian cancer and other factors that might influence the risk to develop ovarian cancer. Logistic regression analyses were performed to estimate the impact of the evaluated factors on the likelihood of mutation detection, by calculating odds ratios and 95% confidence intervals.

Results: seventeen out of 51 patients had a family history of breast and/or ovarian cancer, four patients had a history of breast or endometrial cancer, 11 were diagnosed before the age of 50, and 12 presented a risk of familial predisposition to ovarian cancer higher than 10%. Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03).

Conclusion: in this study, having comorbidities was associated with a lower risk of having a familial predisposition for ovarian cancer. Other factors associated with the risk of ovarian cancer did not have an impact on this predisposition.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalRevista da Associacao Medica Brasileira
Issue number3
Publication statusPublished - 2015


  • ovarian neoplasms
  • hereditary breast and ovarian cancer syndrome
  • neoplastic syndromes
  • hereditary
  • risk factors

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