Association of Skin Autofluorescence Levels With Kidney Function Decline in Patients With Peripheral Artery Disease

Elise Schutte, Lisanne C. de Vos, Helen L. Lutgers, Hiddo J. Lambers Heerspink, Bruce H. R. Wolffenbuttel, Priya Vart, Clark J. Zeebregts, Ron T. Gansevoort*, Joop D. Lefrandt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


Objective Skin autofluorescence (SAF), a measure of advanced glycation end product accumulation, is associated with kidney function. We investigated the association of SAF with rate of kidney function decline in a cohort of patients with peripheral artery disease.

Approach and Results We performed a post hoc analysis of an observational longitudinal cohort study. We included 471 patients with peripheral artery disease, and SAF was measured at baseline. Primary end point was rate of estimated glomerular filtration rate (eGFR) decline. Secondary end points were incidence of eGFR 5 mL/min/1.73 m(2)/y. During a median follow-up of 3 years, the mean change in eGFR per year was -1.84.4 mL/min/1.73 m(2)/y. No significant difference in rate of eGFR decline was observed per 1 arbitrary unit increase in SAF (-0.1 mL/min/1.73 m(2)/y; 95% confidence interval, -0.7 to 0.5; P=0.8). Analyses of the secondary end points showed that there was an association of SAF with incidence of eGFR

Conclusions In conclusion, in this cohort of patients with peripheral artery disease, elevated SAF was associated with lower baseline eGFR. Although SAF has previously been established as a predictor for cardiovascular disease and mortality, it did not predict the rate of kidney function decline during follow-up in this study.

Original languageEnglish
Pages (from-to)1709-1714
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number8
Publication statusPublished - Aug-2016


  • advanced glycosylation end products
  • chronic renal insufficiency
  • diabetes mellitus
  • disease progression
  • peripheral artery disease
  • RISK

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