Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients

WL van der Pol; MD Jansen; JBM Kuks; M de Baets; FGJ Leppers-van de Straat; JHJ Wokke; JGJ van de Winkel; LH van den Berg

doi:10.1016/j.jneuroim.2003.08.043

Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients

WL van der Pol^*, MD Jansen, JBM Kuks, M de Baets, FGJ Leppers-van de Straat, JHJ Wokke, JGJ van de Winkel, LH van den Berg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Abstract

Myasthenia gravis (MG) susceptibility is partially determined by allelic heterogeneity of immune-modulatory genes. IgG receptors (FcgammaR) link the humoral and cellular branches of the immune system, and regulate immune responses and inflammation. Three FcgammaR subclasses (FcgammaRIIa, FcgammaRIIIa, and FcgammaRIIIb) exhibit functional polymorphisms, which affect efficiency of FcgammaR-mediated functions. FcgammaRIIa genotypes, but not FcgammaRIIIa and FcgammaRIIIb genotypes, were differentially distributed among 107 MG patients as compared to 239 healthy controls (Pmuch less than0.01), with a relative increase of the FcgammaRIIa-R/R131 genotype (Odds ratio 2.4, 95% confidence interval 1.4-3.9). These data suggest that the FcgammaRIIa-R/R131 genotype is a marker for susceptibility to MG. (C) 2003 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	144
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2003.08.043
Publication status	Published - Nov-2003

Keywords

myasthenia gravis
Fc gamma R
polymorphism
SYSTEMIC-LUPUS-ERYTHEMATOSUS
MUSCLE ACETYLCHOLINE-RECEPTOR
RISK-FACTORS
RIIA CD32
DISEASE HETEROGENEITY
IMMUNE-COMPLEXES
AMINO-ACID
HUMAN IGG2
IN-VIVO
POLYMORPHISM

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@article{82355cca99ce4ff1b11063595c9471cd,

title = "Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients",

abstract = "Myasthenia gravis (MG) susceptibility is partially determined by allelic heterogeneity of immune-modulatory genes. IgG receptors (FcgammaR) link the humoral and cellular branches of the immune system, and regulate immune responses and inflammation. Three FcgammaR subclasses (FcgammaRIIa, FcgammaRIIIa, and FcgammaRIIIb) exhibit functional polymorphisms, which affect efficiency of FcgammaR-mediated functions. FcgammaRIIa genotypes, but not FcgammaRIIIa and FcgammaRIIIb genotypes, were differentially distributed among 107 MG patients as compared to 239 healthy controls (Pmuch less than0.01), with a relative increase of the FcgammaRIIa-R/R131 genotype (Odds ratio 2.4, 95% confidence interval 1.4-3.9). These data suggest that the FcgammaRIIa-R/R131 genotype is a marker for susceptibility to MG. (C) 2003 Elsevier B.V. All rights reserved.",

keywords = "myasthenia gravis, Fc gamma R, polymorphism, SYSTEMIC-LUPUS-ERYTHEMATOSUS, MUSCLE ACETYLCHOLINE-RECEPTOR, RISK-FACTORS, RIIA CD32, DISEASE HETEROGENEITY, IMMUNE-COMPLEXES, AMINO-ACID, HUMAN IGG2, IN-VIVO, POLYMORPHISM",

author = "{van der Pol}, WL and MD Jansen and JBM Kuks and {de Baets}, M and {Leppers-van de Straat}, FGJ and JHJ Wokke and {van de Winkel}, JGJ and {van den Berg}, LH",

year = "2003",

month = nov,

doi = "10.1016/j.jneuroim.2003.08.043",

language = "English",

volume = "144",

pages = "143--147",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "ELSEVIER SCIENCE BV",

number = "1-2",

}

TY - JOUR

T1 - Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients

AU - van der Pol, WL

AU - Jansen, MD

AU - Kuks, JBM

AU - de Baets, M

AU - Leppers-van de Straat, FGJ

AU - Wokke, JHJ

AU - van de Winkel, JGJ

AU - van den Berg, LH

PY - 2003/11

Y1 - 2003/11

N2 - Myasthenia gravis (MG) susceptibility is partially determined by allelic heterogeneity of immune-modulatory genes. IgG receptors (FcgammaR) link the humoral and cellular branches of the immune system, and regulate immune responses and inflammation. Three FcgammaR subclasses (FcgammaRIIa, FcgammaRIIIa, and FcgammaRIIIb) exhibit functional polymorphisms, which affect efficiency of FcgammaR-mediated functions. FcgammaRIIa genotypes, but not FcgammaRIIIa and FcgammaRIIIb genotypes, were differentially distributed among 107 MG patients as compared to 239 healthy controls (Pmuch less than0.01), with a relative increase of the FcgammaRIIa-R/R131 genotype (Odds ratio 2.4, 95% confidence interval 1.4-3.9). These data suggest that the FcgammaRIIa-R/R131 genotype is a marker for susceptibility to MG. (C) 2003 Elsevier B.V. All rights reserved.

AB - Myasthenia gravis (MG) susceptibility is partially determined by allelic heterogeneity of immune-modulatory genes. IgG receptors (FcgammaR) link the humoral and cellular branches of the immune system, and regulate immune responses and inflammation. Three FcgammaR subclasses (FcgammaRIIa, FcgammaRIIIa, and FcgammaRIIIb) exhibit functional polymorphisms, which affect efficiency of FcgammaR-mediated functions. FcgammaRIIa genotypes, but not FcgammaRIIIa and FcgammaRIIIb genotypes, were differentially distributed among 107 MG patients as compared to 239 healthy controls (Pmuch less than0.01), with a relative increase of the FcgammaRIIa-R/R131 genotype (Odds ratio 2.4, 95% confidence interval 1.4-3.9). These data suggest that the FcgammaRIIa-R/R131 genotype is a marker for susceptibility to MG. (C) 2003 Elsevier B.V. All rights reserved.

KW - myasthenia gravis

KW - Fc gamma R

KW - polymorphism

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - MUSCLE ACETYLCHOLINE-RECEPTOR

KW - RISK-FACTORS

KW - RIIA CD32

KW - DISEASE HETEROGENEITY

KW - IMMUNE-COMPLEXES

KW - AMINO-ACID

KW - HUMAN IGG2

KW - IN-VIVO

KW - POLYMORPHISM

U2 - 10.1016/j.jneuroim.2003.08.043

DO - 10.1016/j.jneuroim.2003.08.043

M3 - Article

SN - 0165-5728

VL - 144

SP - 143

EP - 147

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients

Abstract

Keywords

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