Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression

Peter de Jonge; Jordi Alonso; Dan J. Stein; Andrzej Kiejna; Sergio Aguilar-Gaxiola; Maria Carmen Viana; Zhaorui Liu; Siobhan O'Neill; Ronny Bruffaerts; Jose Miguel Caldas-de-Almeida; Jean-Pierre Lepine; Herbert Matschinger; Daphna Levinson; Giovanni de Girolamo; Akira Fukao; Brendan Bunting; Josep Maria Haro; Jose A. Posada-Villa; Ali Obaid Al-Hamzawi; Maria Elena Medina-Mora; Marina Piazza; Chiyi Hu; Carmen Sasu; Carmen C. W. Lim; Ronald C. Kessler; Kate M. Scott

doi:10.1007/s00125-013-3157-9

Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression

Peter de Jonge^*, Jordi Alonso, Dan J. Stein, Andrzej Kiejna, Sergio Aguilar-Gaxiola, Maria Carmen Viana, Zhaorui Liu, Siobhan O'Neill, Ronny Bruffaerts, Jose Miguel Caldas-de-Almeida, Jean-Pierre Lepine, Herbert Matschinger, Daphna Levinson, Giovanni de Girolamo, Akira Fukao, Brendan Bunting, Josep Maria Haro, Jose A. Posada-Villa, Ali Obaid Al-Hamzawi, Maria Elena Medina-MoraMarina Piazza, Chiyi Hu, Carmen Sasu, Carmen C. W. Lim, Ronald C. Kessler, Kate M. Scott

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

78 Citations (Scopus)

Abstract

Aims/hypotheis No studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.

Methods We performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician's diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.

Results We identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.

Conclusions/interpretation Depression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.

Original language	English
Pages (from-to)	699-709
Number of pages	11
Journal	Diabetologia
Volume	57
Issue number	4
DOIs	https://doi.org/10.1007/s00125-013-3157-9
Publication status	Published - Apr-2014

Keywords

Comorbidity
Depression
Epidemiology
Impulse control disorders
Mental disorders
HEALTH SURVEYS
RISK-FACTOR
EATING-DISORDERS
TYPE-2
METAANALYSIS
PREVALENCE
EPIDEMIOLOGY
MORTALITY
ONSET
SCHIZOPHRENIA

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Associations between DSM-IV mental disorders and diabetes mellitus a role
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Erratum to: Associations between DSM-IV mental disorders and diabetes mellitus : a role for impulse control disorders and depression (vol 57, pg 1269, 2014)
de Jonge, P., Alonso, J., Stein, D. J., Kiejna, A., Aguilar-Gaxiola, S., Viana, M. C., Liu, Z., O'Neill, S., Bruffaerts, R., Caldas-de-Almeida, J. M., Lepine, J.-P., Matschinger, H., Levinson, D., de Girolamo, G., Fukao, A., Bunting, B., Haro, J. M., Posada-Villa, J. A., Al-Hamzawi, A. O. & Elena Medina-Mora, M. & 6 others, Piazza, M., Hu, C., Sasu, C., Lim, C. C. W., Kessler, R. C. & Scott, K. M., Jun-2014, In: Diabetologia. 57, 6, p. 1269-1270 2 p.
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de Jonge, P., Alonso, J., Stein, D. J., Kiejna, A., Aguilar-Gaxiola, S., Viana, M. C., Liu, Z., O'Neill, S., Bruffaerts, R., Caldas-de-Almeida, J. M., Lepine, J.-P., Matschinger, H., Levinson, D., de Girolamo, G., Fukao, A., Bunting, B., Maria Haro, J., Posada-Villa, J. A., Al-Hamzawi, A. O., ... Scott, K. M. (2014). Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression. Diabetologia, 57(4), 699-709. https://doi.org/10.1007/s00125-013-3157-9

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title = "Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression",

abstract = "Aims/hypotheis No studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.Methods We performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician's diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.Results We identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.Conclusions/interpretation Depression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.",

keywords = "Comorbidity, Depression, Epidemiology, Impulse control disorders, Mental disorders, HEALTH SURVEYS, RISK-FACTOR, EATING-DISORDERS, TYPE-2, METAANALYSIS, PREVALENCE, EPIDEMIOLOGY, MORTALITY, ONSET, SCHIZOPHRENIA",

author = "{de Jonge}, Peter and Jordi Alonso and Stein, {Dan J.} and Andrzej Kiejna and Sergio Aguilar-Gaxiola and Viana, {Maria Carmen} and Zhaorui Liu and Siobhan O'Neill and Ronny Bruffaerts and Caldas-de-Almeida, {Jose Miguel} and Jean-Pierre Lepine and Herbert Matschinger and Daphna Levinson and {de Girolamo}, Giovanni and Akira Fukao and Brendan Bunting and {Maria Haro}, Josep and Posada-Villa, {Jose A.} and Al-Hamzawi, {Ali Obaid} and {Elena Medina-Mora}, Maria and Marina Piazza and Chiyi Hu and Carmen Sasu and Lim, {Carmen C. W.} and Kessler, {Ronald C.} and Scott, {Kate M.}",

year = "2014",

month = apr,

doi = "10.1007/s00125-013-3157-9",

language = "English",

volume = "57",

pages = "699--709",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

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de Jonge, P, Alonso, J, Stein, DJ, Kiejna, A, Aguilar-Gaxiola, S, Viana, MC, Liu, Z, O'Neill, S, Bruffaerts, R, Caldas-de-Almeida, JM, Lepine, J-P, Matschinger, H, Levinson, D, de Girolamo, G, Fukao, A, Bunting, B, Maria Haro, J, Posada-Villa, JA, Al-Hamzawi, AO, Elena Medina-Mora, M, Piazza, M, Hu, C, Sasu, C, Lim, CCW, Kessler, RC & Scott, KM 2014, 'Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression', Diabetologia, vol. 57, no. 4, pp. 699-709. https://doi.org/10.1007/s00125-013-3157-9

TY - JOUR

T1 - Associations between DSM-IV mental disorders and diabetes mellitus

T2 - a role for impulse control disorders and depression

AU - de Jonge, Peter

AU - Alonso, Jordi

AU - Stein, Dan J.

AU - Kiejna, Andrzej

AU - Aguilar-Gaxiola, Sergio

AU - Viana, Maria Carmen

AU - Liu, Zhaorui

AU - O'Neill, Siobhan

AU - Bruffaerts, Ronny

AU - Caldas-de-Almeida, Jose Miguel

AU - Lepine, Jean-Pierre

AU - Matschinger, Herbert

AU - Levinson, Daphna

AU - de Girolamo, Giovanni

AU - Fukao, Akira

AU - Bunting, Brendan

AU - Maria Haro, Josep

AU - Posada-Villa, Jose A.

AU - Al-Hamzawi, Ali Obaid

AU - Elena Medina-Mora, Maria

AU - Piazza, Marina

AU - Hu, Chiyi

AU - Sasu, Carmen

AU - Lim, Carmen C. W.

AU - Kessler, Ronald C.

AU - Scott, Kate M.

PY - 2014/4

Y1 - 2014/4

N2 - Aims/hypotheis No studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.Methods We performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician's diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.Results We identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.Conclusions/interpretation Depression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.

AB - Aims/hypotheis No studies have evaluated whether the frequently observed associations between depression and diabetes could reflect the presence of comorbid psychiatric conditions and their associations with diabetes. We therefore examined the associations between a wide range of pre-existing Diagnostic Statistical Manual, 4th edition (DSM-IV) mental disorders with self-reported diagnosis of diabetes.Methods We performed a series of cross-sectional face-to-face household surveys of community-dwelling adults (n = 52,095) in 19 countries. The World Health Organization Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Diabetes was indicated by self-report of physician's diagnosis together with its timing. We analysed the associations between all mental disorders and diabetes, without and with comorbidity adjustment.Results We identified 2,580 cases of adult-onset diabetes mellitus (21 years +). Although all 16 DSM-IV disorders were associated with diabetes diagnosis in bivariate models, only depression (OR 1.3; 95% CI 1.1, 1.5), intermittent explosive disorder (OR 1.6; 95% CI 1.1, 2.1), binge eating disorder (OR 2.6; 95% CI 1.7, 4.0) and bulimia nervosa (OR 2.1; 95% CI 1.3, 3.4) remained after comorbidity adjustment.Conclusions/interpretation Depression and impulse control disorders (eating disorders in particular) were significantly associated with diabetes diagnosis after comorbidity adjustment. These findings support the focus on depression as having a role in diabetes onset, but suggest that this focus may be extended towards impulse control disorders. Acknowledging the comorbidity of mental disorders is important in determining the associations between mental disorders and subsequent diabetes.

KW - Comorbidity

KW - Depression

KW - Epidemiology

KW - Impulse control disorders

KW - Mental disorders

KW - HEALTH SURVEYS

KW - RISK-FACTOR

KW - EATING-DISORDERS

KW - TYPE-2

KW - METAANALYSIS

KW - PREVALENCE

KW - EPIDEMIOLOGY

KW - MORTALITY

KW - ONSET

KW - SCHIZOPHRENIA

U2 - 10.1007/s00125-013-3157-9

DO - 10.1007/s00125-013-3157-9

M3 - Article

SN - 0012-186X

VL - 57

SP - 699

EP - 709

JO - Diabetologia

JF - Diabetologia

IS - 4

ER -

Associations between DSM-IV mental disorders and diabetes mellitus: a role for impulse control disorders and depression

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Erratum to: Associations between DSM-IV mental disorders and diabetes mellitus : a role for impulse control disorders and depression (vol 57, pg 1269, 2014)

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