TY - JOUR
T1 - Associations between DSM-IV mental disorders and onset of self-reported peptic ulcer in the World Mental Health Surveys
AU - Scott, Kate M.
AU - Alonso, Jordi
AU - de Jonge, Peter
AU - Carmen Viana, Maria
AU - Liu, Zhaorui
AU - O'Neill, Siobhan
AU - Aguilar-Gaxiola, Sergio
AU - Bruffaerts, Ronny
AU - Caldas-de-Almeida, Jose Miguel
AU - Stein, Dan J.
AU - Angermeyer, Matthias
AU - Benjet, Corina
AU - de Girolamo, Giovanni
AU - Firuleasa, Ingrid-Laura
AU - Hu, Chiyi
AU - Kiejna, Andrzej
AU - Kovess-Masfety, Viviane
AU - Levinson, Daphna
AU - Nakane, Yoshibumi
AU - Piazza, Marina
AU - Posada-Villa, Jose A.
AU - Khalaf, Mohammad Salih
AU - Lim, Carmen C. W.
AU - Kessler, Ronald C.
PY - 2013/8
Y1 - 2013/8
N2 - Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities.Methods: Face-to-face household surveys conducted in 19 countries (n = 52,095; person years = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset.Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities.Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders. (C) 2013 Elsevier Inc. All rights reserved.
AB - Objective: Recent research demonstrating concurrent associations between mental disorders and peptic ulcers has renewed interest in links between psychological factors and ulcers. However, little is known about associations between temporally prior mental disorders and subsequent ulcer onset. Nor has the potentially confounding role of childhood adversities been explored. The objective of this study was to examine associations between a wide range of temporally prior DSM-IV mental disorders and subsequent onset of ulcer, without and with adjustment for mental disorder comorbidity and childhood adversities.Methods: Face-to-face household surveys conducted in 19 countries (n = 52,095; person years = 2,096,486). The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Peptic ulcer onset was assessed in the same interview by self-report of physician's diagnosis and year of diagnosis. Survival analyses estimated associations between first onset of mental disorders and subsequent ulcer onset.Results: After comorbidity and sociodemographic adjustment, depression, social phobia, specific phobia, post-traumatic stress disorder, intermittent explosive disorder, alcohol and drug abuse disorders were significantly associated with ulcer onset (ORs 1.3-1.6). Increasing number of lifetime mental disorders was associated with ulcer onset in a dose-response fashion. These associations were only slightly attenuated by adjustment for childhood adversities.Conclusions: A wide range of mental disorders were linked with the self-report of subsequent peptic ulcer onset These associations require confirmation in prospective designs, but are suggestive of a role for mental disorders in contributing to ulcer vulnerability, possibly through abnormalities in the physiological stress response associated with mental disorders. (C) 2013 Elsevier Inc. All rights reserved.
KW - Mental disorders
KW - Depression
KW - Anxiety
KW - Alcohol abuse and dependence
KW - Peptic ulcer
KW - CHILDHOOD PHYSICAL ABUSE
KW - POSTTRAUMATIC-STRESS-DISORDER
KW - HELICOBACTER-PYLORI
KW - PSYCHIATRIC-DISORDERS
KW - SOCIAL-CONSEQUENCES
KW - MAJOR DEPRESSION
KW - UNITED-STATES
KW - DISEASE
KW - ADULTS
KW - ANXIETY
U2 - 10.1016/j.jpsychores.2013.04.007
DO - 10.1016/j.jpsychores.2013.04.007
M3 - Article
SN - 0022-3999
VL - 75
SP - 121
EP - 127
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
IS - 2
ER -