Associations between DSM-IV mental disorders and subsequent non-fatal, self-reported stroke

Nicola R. Swain*, Carmen C. W. Lim, Daphna Levinson, Fabian Fiestas, Giovanni de Girolamo, Jacek Moskalewicz, Jean-Pierre Lepine, Jose Posada-Villa, Josep Maria Haro, Maria Elena Medina-Mora, Miguel Xavier, Noboru Lwata, Peter de Jonge, Ronny Bruffaerts, Siobhan O'Neill, Ron C. Kessler, Kate M. Scott

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Objectives: To examine the associations between a wide range of mental disorders and subsequent onset of stroke. Lifecourse timing of stroke was examined using retrospectively reconstructed data from cross-sectional surveys.

Methods: Data from the World Mental Health Surveys were accessed. This data was collected from general population surveys over 17 countries of 87,250 adults. The Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of DSM-IV mental disorders. A weighted subsample (n = 45,288), was used for analysis in the present study. Survival analyses estimated associations between first onset of mental disorders and subsequent stroke onset.

Results: Bivariate models showed that 12/16 mental disorders were associated with subsequent stroke onset (ORs ranging from 1.6 to 3.8). However, after adjustment for mental disorder comorbidity and smoking, only significant relationships between depression and stroke (OR 1.3) and alcohol abuse and stroke (OR 1.5) remained. Among females, having a bipolar disorder was also associated with increased stroke incidence (OR 2.1). Increasing number of mental disorders was associated with stroke onset in a dose-response fashion (OR 3.3 for 5 + disorders).

Conclusions: Depression and alcohol abuse may have specific associations with incidence of non-fatal stroke. General severity of psychopathology may be a more important predictor of non-fatal stroke onset Mental health treatment should be considered as part of stroke risk prevention. Limitations of retrospectively gathered cross sectional surveys design mean further research on the links between mental health and stroke incidence is warranted. (C) 2015 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalJournal of Psychosomatic Research
Volume79
Issue number2
Early online date21-May-2015
DOIs
Publication statusPublished - Aug-2015

Keywords

  • Depression
  • Alcohol abuse
  • Stroke
  • Comorbidity
  • ISCHEMIC-STROKE
  • RISK-FACTORS
  • DEPRESSION
  • MORTALITY
  • ANXIETY
  • WORLD
  • COUNTRIES
  • DISEASES
  • VERSION
  • RECALL

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