Associations of 25(OH) and 1,25(OH)(2) Vitamin D With Long-Term Outcomes in Stable Renal Transplant Recipients

Charlotte A. Keyzer, Ineke J. Riphagen, Michel M. Joosten, Gerjan Navis, Anna C. Muller Kobold, Ido P. Kema, Stephan J. L. Bakker, Martin H. de Borst*, NIGRAM Consortium

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

48 Citations (Scopus)

Abstract

Context: Vitamin D deficiency is common in renal transplant recipients (RTR). The long-term implications of vitamin D deficiency in RTR remain unclear.

Objective: We investigated whether 25(OH) or 1,25(OH)(2) vitamin D levels are associated with mortality, renal function decline, and graft failure in stable RTR.

Design: Observational study with longitudinal design. Followup was 7.0, interquartile range (IQR) 6.2-7.5 years.

Setting: Single-center outpatient clinic.

Participants: 435 stable RTR (51% men, mean age 52 +/- 12 years) were included at a median [IQR] of 6 [3-12] years after kidney transplantation.

Main Outcome Measures: All-cause mortality, annual change of estimated glomerular filtration rate (eGFR), and graft failure.

Results: Mean 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] were 21.6 +/- 9.1 ng/ml and 45.2 +/- 19.0 pg/ml, respectively. During followup, 99 patients (22.8%) died and 44 patients (10.1%) developed graft failure. In univariable analysis, both 25(OH)D and 1,25(OH)(2)D were significantly associated with mortality (hazard ratio [HR], 0.64; 95% confidence interval (CI), 0.51-0.81; P <.001 and HR 0.69 [95% CI, 0.55-0.87], P = .002 per SD increase, respectively). The inverse association of 25(OH)D with mortality remained significant after adjustment for potential confounders (HR 0.68 [95% CI, 0.52-0.89], P = .004 per SD increase). The associations of 1,25(OH)(2)D with mortality and graft failure lost significance after adjustment for renal function. Severe vitamin D deficiency (25[OH]D

Conclusions: Low 25(OH) D is independently associated with an increased risk of all-cause mortality and 25(OH) D <12 ng/ml with a rapid eGFR decline in stable RTR. The association of low 1,25(OH)(2)D with mortality or graft failure depends on renal function. These results should encourage randomised controlled trials evaluating the effect of vitamin D supplementation after kidney transplantation.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number1
DOIs
Publication statusPublished - Jan-2015

Keywords

  • CHRONIC KIDNEY-DISEASE
  • C-REACTIVE PROTEIN
  • CARDIOVASCULAR-DISEASE
  • D DEFICIENCY
  • CIRCULATING MARKERS
  • ALLOGRAFT FUNCTION
  • METABOLIC SYNDROME
  • D SUPPLEMENTATION
  • MORTALITY
  • RISK

Cite this