TY - JOUR
T1 - Associations of early-life pet ownership with asthma and allergic sensitization
T2 - A meta-analysis of more than 77,000 children from the EU Child Cohort Network
AU - Pinot de Moira, Angela
AU - Strandberg-Larsen, Katrine
AU - Bishop, Tom
AU - Pedersen, Marie
AU - Avraam, Demetris
AU - Cadman, Tim
AU - Calas, Lucinda
AU - Casas, Maribel
AU - de Lauzon Guillain, Blandine
AU - Elhakeem, Ahmed
AU - Esplugues, Ana
AU - Estarlich, Marisa
AU - Foong, Rachel E.
AU - Haakma, Sido
AU - Harris, Jennifer R.
AU - Huang, Rae Chi
AU - Inskip, Hazel
AU - Lertxundi, Aitana
AU - Mensink-Bout, Sara M.
AU - Nader, Johanna L.T.
AU - Pizzi, Costanza
AU - Popovic, Maja
AU - Salika, Theodosia
AU - Sunyer, Jordi
AU - Van Meel, Evelien R.
AU - Swertz, Morris A.
AU - Jaddoe, Vincent W.V.
AU - Burton, Paul
AU - Duijts, Liesbeth
AU - Nybo Andersen, Anne Marie
N1 - Funding Information:
The LifeCycle project received funding from the European Union's (EU's) Horizon 2020 research and innovation programme (grant 733206 LifeCycle) and was supported by the EUCAN-Connect project under the EU's Horizon 2020 research and innovation programme (grant 824989). Support was also provided by the following: a Lundbeck Foundation fellowship (R264-2017-3099 [to A.P.]); a Sapera Aude: DFF-Reasearch Leader grant (grant 8045-00047B [to K.S.L.); a Walter A. Rosenblith New Investigator Award from the Health Effects Institute, Boston, Massachusetts (grant CR-83590201 [to M.P.]); a European Research Council Starting Grant (grant 758151 [to M.P.]); the National Institute of Health ([to M.P.]), the EU ([to M.P.]), and the city of Copenhagen ([to M.P.]), a Miguel Servet fellowship (CP16/00128) funded by Instituto de Salud Carlos III and cofunded by the European Social Fund Investing in Your Future (to M.C.); a National Health and Medical Research Council (NHMRC) fellowship (grant 114032 [to R.E.F.]); an NHMRC fellowship (grant 1053384 [to R.C.H.]) and NHMRC EU (grant 114285 [to R.C.H.]); the EU's Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health ALPHABET project (grant 696295; 2017 [to L.D.]), ZonMw The Netherlands (grant 529051014 [2017] [to L.D.]); and the EUCAN-Connect project under the EU's Horizon 2020 research and innovation programme (grant 824989 [to T.B.]). This article reflects only the authors’ views; the commission is not responsible for any use that may be made of the information that it contains. All study-specific acknowledgments and funding are presented in the Supplementary Information 4 and 5 (available in the Online Repository at www.jacionline.org).
Funding Information:
The LifeCycle project received funding from the European Union’s (EU's) Horizon 2020 research and innovation programme (grant 733206 LifeCycle) and was supported by the EUCAN-Connect project under the EU’s Horizon 2020 research and innovation programme (grant 824989 ). Support was also provided by the following: a Lundbeck Foundation fellowship (R264-2017-3099 [to A.P.]); a Sapera Aude: DFF-Reasearch Leader grant (grant 8045-00047B [to K.S.L.); a Walter A. Rosenblith New Investigator Award from the Health Effects Institute, Boston, Massachusetts (grant CR-83590201 [to M.P.]); a European Research Council Starting Grant (grant 758151 [to M.P.]); the National Institute of Health ([to M.P.]), the EU ([to M.P.]), and the city of Copenhagen ([to M.P.]), a Miguel Servet fellowship (CP16/00128) funded by Instituto de Salud Carlos III and cofunded by the European Social Fund Investing in Your Future (to M.C.); a National Health and Medical Research Council (NHMRC) fellowship (grant 114032 [to R.E.F.]); an NHMRC fellowship (grant 1053384 [to R.C.H.]) and NHMRC EU (grant 114285 [to R.C.H.]); the EU's Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health ALPHABET project (grant 696295; 2017 [to L.D.]), ZonMw The Netherlands (grant 529051014 [2017] [to L.D.]); and the EUCAN-Connect project under the EU’s Horizon 2020 research and innovation programme (grant 824989 [to T.B.]). This article reflects only the authors’ views; the commission is not responsible for any use that may be made of the information that it contains. All study-specific acknowledgments and funding are presented in the Supplementary Information 4 and 5 (available in the Online Repository at www.jacionline.org ).
Publisher Copyright:
© 2022 The Authors
PY - 2022/7
Y1 - 2022/7
N2 - Background: Studies examining associations of early-life cat and dog ownership with childhood asthma have reported inconsistent results. Several factors could explain these inconsistencies, including type of pet, timing, and degree of exposure.Objective: Our aim was to study associations of early-life cat and dog ownership with asthma in school-aged children, including the role of type (cat vs dog), timing (never, prenatal, or early childhood), and degree of ownership (number of pets owned), and the role of allergic sensitization.Methods: We used harmonized data from 77,434 mother-child dyads from 9 birth cohorts in the European Union Child Cohort Network when the child was 5 to 11 years old. Associations were examined through the DataSHIELD platform by using adjusted logistic regression models, which were fitted separately for each cohort and combined by using random effects meta-analysis.Results: The prevalence of early-life cat and dog ownership ranged from 12% to 45% and 7% to 47%, respectively, and the prevalence of asthma ranged from 2% to 20%. There was no overall association between either cat or dog ownership and asthma (odds ratio [OR] = 0.97 [95% CI = 0.87-1.09] and 0.92 [95% CI = 0.85-1.01], respectively). Timing and degree of ownership did not strongly influence associations. Cat and dog ownership were also not associated with cat- and dog-specific allergic sensitization (OR = 0.92 [95% CI = 0.75-1.13] and 0.93 [95% CI = 0.57-1.54], respectively). However, cat- and dog-specific allergic sensitization was strongly associated with school-age asthma (OR = 6.69 [95% CI = 4.91-9.10] and 5.98 [95% CI = 3.14-11.36], respectively). There was also some indication of an interaction between ownership and sensitization, suggesting that ownership may exacerbate the risks associated with pet-specific sensitization but offer some protection against asthma in the absence of sensitization.Conclusion: Our findings do not support early-life cat and dog ownership in themselves increasing the risk of school-age asthma, but they do suggest that ownership may potentially exacerbate the risks associated with cat- and dog-specific allergic sensitization.
AB - Background: Studies examining associations of early-life cat and dog ownership with childhood asthma have reported inconsistent results. Several factors could explain these inconsistencies, including type of pet, timing, and degree of exposure.Objective: Our aim was to study associations of early-life cat and dog ownership with asthma in school-aged children, including the role of type (cat vs dog), timing (never, prenatal, or early childhood), and degree of ownership (number of pets owned), and the role of allergic sensitization.Methods: We used harmonized data from 77,434 mother-child dyads from 9 birth cohorts in the European Union Child Cohort Network when the child was 5 to 11 years old. Associations were examined through the DataSHIELD platform by using adjusted logistic regression models, which were fitted separately for each cohort and combined by using random effects meta-analysis.Results: The prevalence of early-life cat and dog ownership ranged from 12% to 45% and 7% to 47%, respectively, and the prevalence of asthma ranged from 2% to 20%. There was no overall association between either cat or dog ownership and asthma (odds ratio [OR] = 0.97 [95% CI = 0.87-1.09] and 0.92 [95% CI = 0.85-1.01], respectively). Timing and degree of ownership did not strongly influence associations. Cat and dog ownership were also not associated with cat- and dog-specific allergic sensitization (OR = 0.92 [95% CI = 0.75-1.13] and 0.93 [95% CI = 0.57-1.54], respectively). However, cat- and dog-specific allergic sensitization was strongly associated with school-age asthma (OR = 6.69 [95% CI = 4.91-9.10] and 5.98 [95% CI = 3.14-11.36], respectively). There was also some indication of an interaction between ownership and sensitization, suggesting that ownership may exacerbate the risks associated with pet-specific sensitization but offer some protection against asthma in the absence of sensitization.Conclusion: Our findings do not support early-life cat and dog ownership in themselves increasing the risk of school-age asthma, but they do suggest that ownership may potentially exacerbate the risks associated with cat- and dog-specific allergic sensitization.
KW - accessible
KW - allergic sensitization
KW - and reusable)
KW - asthma
KW - birth cohort
KW - Cat
KW - children
KW - dog
KW - exposure
KW - FAIR (findable
KW - interoperable
KW - life course epidemiology
KW - meta-analysis
KW - ownership
U2 - 10.1016/j.jaci.2022.01.023
DO - 10.1016/j.jaci.2022.01.023
M3 - Article
C2 - 35150722
AN - SCOPUS:85125526955
SN - 0091-6749
VL - 150
SP - 82
EP - 92
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -