@inbook{8b5163be8ece460886bc26b91c44c467,
title = "Asymmetric Allylic Substitutions Using Organometallic Reagents",
abstract = "This chapter summarises recent progress in Cu-catalysed asymmetric allylic alkylation (AAA) with organometallic compounds, including Grignard, organolithium, organoaluminium, organozinc and organozirconium reagents. New reaction conditions and chiral ligands that improve these transformations or allow to overcome previous limitations associated with chemo-, regio- and enantioselectivities will be described. Moreover, a description of new ligands and conditions for the introduction of previously elusive nucleophiles, such as highly reactive organolithium compounds, is included together with a brief mechanistic discussion. Additionally, new challenging substrates which provide densely functionalised building blocks, as well as new synthetic applications that take advantage of the terminal olefin formed in these reactions, will be described.",
keywords = "Allylation, Asymmetric allylic substitution, Copper catalysis, Enantioselectivity, Organometallic reagents, CATALYZED ENANTIOSELECTIVE SYNTHESIS, QUATERNARY STEREOGENIC CENTERS, RING-CLOSING METATHESIS, GRIGNARD-REAGENTS, ORGANOLITHIUM REAGENTS, OXABICYCLIC ALKENES, CONJUGATE ADDITION, KINETIC RESOLUTION, VINYLALUMINUM REAGENTS, HYDROXYALKYL NHC",
author = "Valentin Hornillos and Jean-Baptiste Gualtierotti and Feringa, {Ben L.}",
year = "2016",
doi = "10.1007/3418_2015_165",
language = "English",
isbn = "978-3-319-33412-7",
series = "Topics in Organometallic Chemistry",
publisher = "Springer-Verlag Berlin Heidelberg",
pages = "1--39",
editor = "Harutyunyan",
booktitle = "PROGRESS IN ENANTIOSELECTIVE CU(I)-CATALYZED FORMATION OF STEREOGENIC CENTERS",
}