Asymmetric Cu-catalyzed 1,2 and 1,4-additions of Grignard reagents: Development of new substrates and their application in total synthesis

Beatriz Carmen Calvo Gonzalez

Asymmetric Cu-catalyzed 1,2 and 1,4-additions of Grignard reagents: Development of new substrates and their application in total synthesis

Beatriz Carmen Calvo Gonzalez

Chemical Biology 2

Research output: Thesis › Thesis fully internal (DIV)

649 Downloads (Pure)

Abstract

In this thesis, copper-catalyzed asymmetric 1,2 and 1,4-additions of Grignard reagents to different α,β-unsaturated substituted enones are described. The application of this methodology to the enantioselective synthesis of steroid hybrids, is also demonstrated.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	Minnaard, Adriaan, Supervisor Browne, Wesley, Assessment committee Dömling, Alex, Assessment committee van der Eycken, E.V. , Assessment committee, External person
Award date	7-Sept-2018
Place of Publication	[Groningen]
Publisher	University of Groningen
Print ISBNs	978-94-034-09992-4
Electronic ISBNs	978-94-034-09991-7
Publication status	Published - 2018

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Title and contentsFinal publisher's version, 272 KB
Chapter 1Final publisher's version, 1.49 MB
Chapter 2Final publisher's version, 402 KB
Chapter 3Final publisher's version, 403 KB
Chapter 4Final publisher's version, 711 KB
Outlook and perspectivesFinal publisher's version, 82.3 KB
SummaryFinal publisher's version, 253 KB
AcknowledgementsFinal publisher's version, 62.3 KB
List of abbreviationsFinal publisher's version, 81.6 KB
Complete thesisFinal publisher's version, 3.1 MB
PropositionsFinal publisher's version, 48.6 KB

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title = "Asymmetric Cu-catalyzed 1,2 and 1,4-additions of Grignard reagents: Development of new substrates and their application in total synthesis",

abstract = "In this thesis, copper-catalyzed asymmetric 1,2 and 1,4-additions of Grignard reagents to different α,β-unsaturated substituted enones are described. The application of this methodology to the enantioselective synthesis of steroid hybrids, is also demonstrated.",

author = "{Calvo Gonzalez}, {Beatriz Carmen}",

year = "2018",

language = "English",

isbn = "978-94-034-09992-4",

publisher = "University of Groningen",

school = "University of Groningen",

}

TY - BOOK

T1 - Asymmetric Cu-catalyzed 1,2 and 1,4-additions of Grignard reagents

T2 - Development of new substrates and their application in total synthesis

AU - Calvo Gonzalez, Beatriz Carmen

PY - 2018

Y1 - 2018

N2 - In this thesis, copper-catalyzed asymmetric 1,2 and 1,4-additions of Grignard reagents to different α,β-unsaturated substituted enones are described. The application of this methodology to the enantioselective synthesis of steroid hybrids, is also demonstrated.

AB - In this thesis, copper-catalyzed asymmetric 1,2 and 1,4-additions of Grignard reagents to different α,β-unsaturated substituted enones are described. The application of this methodology to the enantioselective synthesis of steroid hybrids, is also demonstrated.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-09992-4

PB - University of Groningen

CY - [Groningen]

ER -

Asymmetric Cu-catalyzed 1,2 and 1,4-additions of Grignard reagents: Development of new substrates and their application in total synthesis

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