Asymmetric Cu-catalyzed 1,2 and 1,4-additions of Grignard reagents: Development of new substrates and their application in total synthesis

Beatriz Carmen Calvo Gonzalez

Research output: ThesisThesis fully internal (DIV)

539 Downloads (Pure)

Abstract

In this thesis, copper-catalyzed asymmetric 1,2 and 1,4-additions of Grignard reagents to different α,β-unsaturated substituted enones are described. The application of this methodology to the enantioselective synthesis of steroid hybrids, is also demonstrated.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
Supervisors/Advisors
  • Minnaard, Adriaan, Supervisor
  • Browne, Wesley, Assessment committee
  • Dömling, Alex, Assessment committee
  • van der Eycken, E.V. , Assessment committee, External person
Award date7-Sept-2018
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-034-09992-4
Electronic ISBNs978-94-034-09991-7
Publication statusPublished - 2018

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