Atherosclerotic plaque development and instability: A dual role for VEGF

Pieter W. Holm, Riemer H. J. A. Slart, Clark J. Zeebregts, Jan L. Hillebrands, Rene A. Tio*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF), a potent growth factor for endothelial cells and inducer of angiogenesis, is important for endothelial integrity and thus for vascular function. On the other hand, VEGF may enhance the pathophysiologic mechanism of plaque formation and plaque destabilization. In this review we discuss the data available so far for VEGF as angiogenic and/or inflammatory cytokine in the vulnerable atherosclerotic plaque.

Original languageEnglish
Article number906849430
Pages (from-to)257-264
Number of pages8
JournalAnnals of medicine
Volume41
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Angiogenesis
  • atherosclerosis
  • endothelium
  • VEGF
  • ENDOTHELIAL GROWTH-FACTOR
  • INTERCELLULAR-ADHESION MOLECULE-1
  • CORONARY-ARTERY-DISEASE
  • GENE-TRANSFER
  • INFLAMMATORY ANGIOGENESIS
  • MYOCARDIAL-INFARCTION
  • LEUKOCYTE RECRUITMENT
  • ANGINA-PECTORIS
  • TYROSINE KINASE
  • CAROTID PLAQUE

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