Atmospheric Pressure Variation is a Delayed Trigger for Aneurysmal Subarachnoid Hemorrhage

Carlina E van Donkelaar, Adriaan R E Potgieser, Henk Groen, Mahrouz Foumani, Herrer Abdulrahman, Rob Sluijter, J Marc C van Dijk, Rob J M Groen

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Abstract

OBJECTIVE: There is an ongoing search for conditions that induce spontaneous subarachnoid hemorrhage (SAH). The seasonal pattern of SAH is shown in a large meta-analysis of the literature, but its explanation remains undecided. There is a clear need for sound meteorologic data to further elucidate the seasonal influence on SAH. Because of the stable and densely monitored atmospheric situation in the north of the Netherlands, we reviewed our unique cohort on the seasonal incidence of SAH and the association between SAH and local atmospheric changes.

METHODS: Our observational cohort study included 1535 patients with spontaneous SAH admitted to our neurovascular center in the north of the Netherlands between 2000 and 2015. Meteorologic data could be linked to the day of the ictus. To compare SAH incidences over the year and to test the association with meteorologic conditions, incidence rate ratios (IRRs) with corresponding 95% confidence intervals (Cis) were used, calculated by Poisson regression analyses.

RESULTS: Atmospheric pressure variations were significantly associated with aneurysmal SAH. In particular, the pressure change on the second and third day before the ictus was independently correlated to a higher incidence of aneurysmal SAH (IRR, 1.11; 95% CI, 1.00-1.23). The IRR for aneurysmal SAH in July was calculated 0.67 (95% CI, 0.49-0.92) after adjustment for temperature and atmospheric pressure changes.

CONCLUSIONS: Atmospheric pressure variations are a delayed trigger for aneurysmal SAH. Also, a significantly decreased incidence of aneurysmal SAH was noted in July.

Original languageEnglish
Pages (from-to)E783-E790
Number of pages8
JournalWorld neurosurgery
Volume112
Early online date2-Feb-2018
DOIs
Publication statusPublished - Apr-2018

Keywords

  • Aneurysm
  • Atmospheric pressure
  • Inflammation
  • Subarachnoid hemorrhage
  • Season
  • Weather
  • BAROMETRIC-PRESSURE
  • METEOROLOGICAL FACTORS
  • CLIMATIC CONDITIONS
  • CEREBRAL ANEURYSMS
  • SEASONAL-VARIATION
  • RUPTURE
  • WEATHER
  • RISK
  • ASSOCIATION
  • METAANALYSIS

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