Atorvastatin (Lipitor) by MCR

Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Dömling*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
238 Downloads (Pure)

Abstract

A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses.
Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume10
Issue number3
DOIs
Publication statusPublished - 14-Mar-2019

Keywords

  • Atorvastatin
  • convergent synthesis
  • generics
  • münchnone
  • Ugi reaction
  • CALCIUM
  • PYRROLE-IMIDAZOLE POLYAMIDES
  • TISSUE-SELECTIVE INHIBITOR
  • HMG-COA REDUCTASE
  • MULTICOMPONENT REACTIONS
  • EFFICIENT SYNTHESIS
  • KEY INTERMEDIATE
  • HIGHLY POTENT
  • UGI REACTION
  • ISOCYANIDE

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