ATP-dependent proteases that also chaperone protein biogenesis

CK Suzuki; M Rep; JM vanDijl; K Suda; LA Grivell; G Schatz

ATP-dependent proteases that also chaperone protein biogenesis

CK Suzuki^*, M Rep, JM vanDijl, K Suda, LA Grivell, G Schatz

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

199 Citations (Scopus)

Abstract

The ATP-dependent proteases Clp and FtsH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes. The coordination of such processes with selective proteolysis may function in the quality control of protein biogenesis.

Original language	English
Pages (from-to)	118-123
Number of pages	6
Journal	Trends in Biochemical Sciences
Volume	22
Issue number	4
Publication status	Published - Apr-1997

Keywords

ESCHERICHIA-COLI FTSH
HEAT-SHOCK PROTEIN
SACCHAROMYCES-CEREVISIAE
MITOCHONDRIAL-FUNCTION
PUTATIVE ATPASES
CLP PROTEASE
FAMILY
DEGRADATION
MEMBER
GENE

Cite this

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title = "ATP-dependent proteases that also chaperone protein biogenesis",

abstract = "The ATP-dependent proteases Clp and FtsH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes. The coordination of such processes with selective proteolysis may function in the quality control of protein biogenesis.",

keywords = "ESCHERICHIA-COLI FTSH, HEAT-SHOCK PROTEIN, SACCHAROMYCES-CEREVISIAE, MITOCHONDRIAL-FUNCTION, PUTATIVE ATPASES, CLP PROTEASE, FAMILY, DEGRADATION, MEMBER, GENE",

author = "CK Suzuki and M Rep and JM vanDijl and K Suda and LA Grivell and G Schatz",

year = "1997",

month = apr,

language = "English",

volume = "22",

pages = "118--123",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

publisher = "ELSEVIER SCIENCE LONDON",

number = "4",

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TY - JOUR

T1 - ATP-dependent proteases that also chaperone protein biogenesis

AU - Suzuki, CK

AU - Rep, M

AU - vanDijl, JM

AU - Suda, K

AU - Grivell, LA

AU - Schatz, G

PY - 1997/4

Y1 - 1997/4

N2 - The ATP-dependent proteases Clp and FtsH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes. The coordination of such processes with selective proteolysis may function in the quality control of protein biogenesis.

AB - The ATP-dependent proteases Clp and FtsH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes. The coordination of such processes with selective proteolysis may function in the quality control of protein biogenesis.

KW - ESCHERICHIA-COLI FTSH

KW - HEAT-SHOCK PROTEIN

KW - SACCHAROMYCES-CEREVISIAE

KW - MITOCHONDRIAL-FUNCTION

KW - PUTATIVE ATPASES

KW - CLP PROTEASE

KW - FAMILY

KW - DEGRADATION

KW - MEMBER

KW - GENE

M3 - Review article

VL - 22

SP - 118

EP - 123

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 4

ER -