Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Aisling Mulligan; Richard J. L. Anney; Myra O'Regan; Wai Chen; Louise Butler; Michael Fitzgerald; Jan Buitelaar; Hans-Christoph Steinhausen; Aribert Rothenberger; Ruud Minderaa; Judith Nijmeijer; Pieter J. Hoekstra; Robert D. Oades; Herbert Roeyers; Cathelijne Buschgens; Hanna Christiansen; Barbara Franke; Isabel Gabriels; Catharina Hartman; Jonna Kuntsi; Rafaela Marco; Sheera Meidad; Ueli Mueller; Lamprini Psychogiou; Nanda Rommelse; Margaret Thompson; Henrik Uebel; Tobias Banaschewski; Richard Ebstein; Jacques Eisenberg; Iris Manor; Ana Miranda; Fernando Mulas; Joseph Sergeant; Edmund Sonuga-Barke; Phil Asherson; Stephen V. Faraone; Michael Gill

doi:10.1007/s10803-008-0621-3

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Aisling Mulligan^*
, Richard J. L. Anney
, Myra O'Regan
, Wai Chen
, Louise Butler
, Michael Fitzgerald
, Jan Buitelaar
, Hans-Christoph Steinhausen
, Aribert Rothenberger
, Ruud Minderaa
, Judith Nijmeijer
, Pieter J. Hoekstra
, Robert D. Oades
, Herbert Roeyers
, Cathelijne Buschgens
, Hanna Christiansen
, Barbara Franke
, Isabel Gabriels
, Catharina Hartman
, Jonna Kuntsi

Rafaela Marco, Sheera Meidad, Ueli Mueller, Lamprini Psychogiou, Nanda Rommelse, Margaret Thompson, Henrik Uebel, Tobias Banaschewski, Richard Ebstein, Jacques Eisenberg, Iris Manor, Ana Miranda, Fernando Mulas, Joseph Sergeant, Edmund Sonuga-Barke, Phil Asherson, Stephen V. Faraone, Michael Gill

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

171 Citations (Scopus)

52 Downloads (Pure)

Abstract

It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.

Original language	English
Pages (from-to)	197-209
Number of pages	13
Journal	Journal of Autism and Developmental Disorders
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/s10803-008-0621-3
Publication status	Published - Feb-2009

Keywords

ADHD
Autism
Familiality
Oppositional disorders
Motor disorder
Language disorder
DEFICIT-HYPERACTIVITY DISORDER
PERVASIVE DEVELOPMENTAL DISORDER
CHILDRENS-COMMUNICATION-CHECKLIST
SPECTRUM DISORDERS
GENERAL-POPULATION
SOCIAL DISABILITY
TWIN SAMPLE
QUESTIONNAIRE
COMORBIDITY

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10.1007/s10803-008-0621-3

Autism symptoms in Attention-Deficit/Hyperactivity DisorderFinal publisher's version, 272 KBLicence: Taverne

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Autism symptoms in attention-deficit/hyperactivity disorder: A familial trait which correlates with conduct, oppositional defiant, language and motor disorders (Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-008-0621-3)
Mulligan, A., Anney, R. J. L., O'Regan, M., Chen, W., Butler, L., Fitzgerald, M., Buitelaar, J., Steinhausen, H. C., Rothenberger, A., Minderaa, R., Nijmeijer, J., Hoekstra, P. J., Oades, R. D., Roeyers, H., Buschgens, C., Christiansen, H., Franke, B., Gabriels, I., Hartman, C. & Kuntsi, J. & 18 others, Marco, R., Meidad, S., Müller, U. C., Psychogiou, L., Rommelse, N., Thompson, M., Uebel, H., Banaschewski, T., Ebstein, R., Eisenberg, J., Manor, I., Miranda, A., Mulas, F., Sergeant, J., Sonuga-Barke, E., Asherson, P., Faraone, S. V. & Gill, M., Feb-2009, In: Journal of Autism and Developmental Disorders. 39, 2, p. 210-211 2 p.
Research output: Contribution to journal › Erratum

Open Access

5 Citations (Scopus)

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Mulligan, A., Anney, R. J. L., O'Regan, M., Chen, W., Butler, L., Fitzgerald, M., Buitelaar, J., Steinhausen, H.-C., Rothenberger, A., Minderaa, R., Nijmeijer, J., Hoekstra, P. J., Oades, R. D., Roeyers, H., Buschgens, C., Christiansen, H., Franke, B., Gabriels, I., Hartman, C., ... Gill, M. (2009). Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders. Journal of Autism and Developmental Disorders, 39(2), 197-209. https://doi.org/10.1007/s10803-008-0621-3

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title = "Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders",

abstract = "It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31\%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7\%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.",

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author = "Aisling Mulligan and Anney, \{Richard J. L.\} and Myra O'Regan and Wai Chen and Louise Butler and Michael Fitzgerald and Jan Buitelaar and Hans-Christoph Steinhausen and Aribert Rothenberger and Ruud Minderaa and Judith Nijmeijer and Hoekstra, \{Pieter J.\} and Oades, \{Robert D.\} and Herbert Roeyers and Cathelijne Buschgens and Hanna Christiansen and Barbara Franke and Isabel Gabriels and Catharina Hartman and Jonna Kuntsi and Rafaela Marco and Sheera Meidad and Ueli Mueller and Lamprini Psychogiou and Nanda Rommelse and Margaret Thompson and Henrik Uebel and Tobias Banaschewski and Richard Ebstein and Jacques Eisenberg and Iris Manor and Ana Miranda and Fernando Mulas and Joseph Sergeant and Edmund Sonuga-Barke and Phil Asherson and Faraone, \{Stephen V.\} and Michael Gill",

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language = "English",

volume = "39",

pages = "197--209",

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Mulligan, A, Anney, RJL, O'Regan, M, Chen, W, Butler, L, Fitzgerald, M, Buitelaar, J, Steinhausen, H-C, Rothenberger, A, Minderaa, R, Nijmeijer, J, Hoekstra, PJ, Oades, RD, Roeyers, H, Buschgens, C, Christiansen, H, Franke, B, Gabriels, I, Hartman, C, Kuntsi, J, Marco, R, Meidad, S, Mueller, U, Psychogiou, L, Rommelse, N, Thompson, M, Uebel, H, Banaschewski, T, Ebstein, R, Eisenberg, J, Manor, I, Miranda, A, Mulas, F, Sergeant, J, Sonuga-Barke, E, Asherson, P, Faraone, SV & Gill, M 2009, 'Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders', Journal of Autism and Developmental Disorders, vol. 39, no. 2, pp. 197-209. https://doi.org/10.1007/s10803-008-0621-3

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders. / Mulligan, Aisling; Anney, Richard J. L.; O'Regan, Myra et al.
In: Journal of Autism and Developmental Disorders, Vol. 39, No. 2, 02.2009, p. 197-209.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Autism symptoms in Attention-Deficit/Hyperactivity Disorder

T2 - A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

AU - Mulligan, Aisling

AU - Anney, Richard J. L.

AU - O'Regan, Myra

AU - Chen, Wai

AU - Butler, Louise

AU - Fitzgerald, Michael

AU - Buitelaar, Jan

AU - Steinhausen, Hans-Christoph

AU - Rothenberger, Aribert

AU - Minderaa, Ruud

AU - Nijmeijer, Judith

AU - Hoekstra, Pieter J.

AU - Oades, Robert D.

AU - Roeyers, Herbert

AU - Buschgens, Cathelijne

AU - Christiansen, Hanna

AU - Franke, Barbara

AU - Gabriels, Isabel

AU - Hartman, Catharina

AU - Kuntsi, Jonna

AU - Marco, Rafaela

AU - Meidad, Sheera

AU - Mueller, Ueli

AU - Psychogiou, Lamprini

AU - Rommelse, Nanda

AU - Thompson, Margaret

AU - Uebel, Henrik

AU - Banaschewski, Tobias

AU - Ebstein, Richard

AU - Eisenberg, Jacques

AU - Manor, Iris

AU - Miranda, Ana

AU - Mulas, Fernando

AU - Sergeant, Joseph

AU - Sonuga-Barke, Edmund

AU - Asherson, Phil

AU - Faraone, Stephen V.

AU - Gill, Michael

PY - 2009/2

Y1 - 2009/2

N2 - It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.

AB - It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.

KW - ADHD

KW - Autism

KW - Familiality

KW - Oppositional disorders

KW - Motor disorder

KW - Language disorder

KW - DEFICIT-HYPERACTIVITY DISORDER

KW - PERVASIVE DEVELOPMENTAL DISORDER

KW - CHILDRENS-COMMUNICATION-CHECKLIST

KW - SPECTRUM DISORDERS

KW - GENERAL-POPULATION

KW - SOCIAL DISABILITY

KW - TWIN SAMPLE

KW - QUESTIONNAIRE

KW - COMORBIDITY

U2 - 10.1007/s10803-008-0621-3

DO - 10.1007/s10803-008-0621-3

M3 - Article

SN - 0162-3257

VL - 39

SP - 197

EP - 209

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 2

ER -

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders

Abstract

Keywords

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Research output

Autism symptoms in attention-deficit/hyperactivity disorder: A familial trait which correlates with conduct, oppositional defiant, language and motor disorders (Journal of Autism and Developmental Disorders DOI: 10.1007/s10803-008-0621-3)

Cite this