Automated erythrocytapheresis in severe falciparum malaria: A critical appraisal

Jellie A. Nieuwenhuis, John H. J. M. Meertens, Jan G. Zijlstra, Jack J. M. Ligtenberg, Jaap E. Tulleken, Tjip S. van der Werf*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Imported falciparum malaria is increasing in Western countries. In patients with severe disease, exchange transfusion has been added to antimalarial and conventional supportive therapy to increase removal of parasitized erythrocytes, but hemodynamic compromise limits its use; automated erythrocytapheresis may be advantageous. We review published reports of patients with severe falciparum malaria treated by automated erythrocytapheresis combined with standard therapy and add three more cases to the literature. No studies have been conducted to evaluate its clinical efficacy, and this adjunct therapy should therefore be considered as salvage therapy. Apheresis of red cells appears feasible, safe and effective in rapidly reducing parasite count. (c) 2006 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalACTA TROPICA
Volume98
Issue number3
DOIs
Publication statusPublished - Jul-2006

Keywords

  • falciparum malaria
  • critical care
  • automated erythrocytapheresis
  • exchange transfusion
  • EXCHANGE-TRANSFUSION
  • CEREBRAL MALARIA
  • BLOOD-TRANSFUSION
  • CELL EXCHANGE
  • HYPERPARASITEMIA
  • ADJUNCT

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