Autophagosome Maturation and Fusion

Fulvio Reggiori, Christian Ungermann

Research output: Contribution to journalReview articlepeer-review

176 Citations (Scopus)
867 Downloads (Pure)

Abstract

Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes. (C) 2017 The Authors. Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)486-496
Number of pages11
JournalJournal of Molecular Biology
Volume429
Issue number4
DOIs
Publication statusPublished - 17-Feb-2017

Keywords

  • autophagosome
  • lysosome
  • ATG protein
  • SNARE
  • membrane fusion
  • HOMOTYPIC VACUOLE FUSION
  • HOPS TETHERING COMPLEX
  • SNARE SYNTAXIN 17
  • SACCHAROMYCES-CEREVISIAE
  • PHOSPHATIDYLINOSITOL 3-PHOSPHATE
  • SELECTIVE AUTOPHAGY
  • LYSOSOME FUSION
  • CAENORHABDITIS-ELEGANS
  • ATG8-PE DECONJUGATION
  • VESICLE FORMATION

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